Quetiapine is an atypical antipsychotic approved for the treatment of patients with psychotic disorders. Since approvement several case reports about intoxication with quetiapine were linked mainly with tachycardia, QT(c)-prolongation, somnolence, and hyperglycemia. Here, we present the first case report of an intoxication with an extreme overdose of quetiapine (36 g), ingested by a 32-year-old...

INTRODUCTION Delirium affects up to 80% of patients admitted to intensive care units (ICUs) and contributes to increased morbidity and mortality. Haloperidol is the gold standard for treatment, although quetiapine has been successfully used in the management of delirium. METHODS We conducted a retrospective study of patients admitted to the ICU between February 2008 and May 2010 who were pres...

BACKGROUND Patients with major depressive disorder (MDD) accompanied by physical symptoms may be less responsive to antidepressant treatment. Quetiapine has been evaluated in the treatment of bipolar depression and has been recently approved as an add-on therapy for unipolar depression. Less is known about the efficacy of combination therapies in patients suffering from MDD with somatic symptom...

30 Wake Forest School of Medicine This study examined the effects of venlafaxine and quetiapine in a nonhuman primate model predictive of antidepressant drug effects. Twelve experimentally naïve male cynomolgus monkeys were trained to respond under a food-reinforcement schedule shown to have predictive validity in models of antidepressant activity (a differentialreinforcement-of-low rates; DRL ...

OBJECTIVE Quetiapine is an atypical antipsychotic that has been used off-label for the treatment of intensive care unit (ICU) delirium in the adult population, with studies demonstrating both efficacy and a favorable safety profile. Although there is a potential role for quetiapine in the treatment of pediatric ICU delirium, there has been no systematic reporting to date of safety in this patie...

BACKGROUND Patients with major depression refractory to repeated pharmacological trials (TRD) may remain symptomatic for many years after their index episode. Augmentation strategies (with lithium or an atypical antipsychotic) or combining an antidepressant with short-term psychotherapy have been used with relative success in these patients. The aim of this study was to assess the effectiveness...

Behavioral and psychological symptoms in dementia (BPSD) include an array of neuropsychiatric symptoms, such as delusions, hallucinations, aggression, and agitation. In recent years, the use of antipsychotics, both conventional and atypical, has been widely debated because of concerns about their safety in treating behavioral disturbances in elderly patients affected with dementia, and the poss...

Quetiapine is next to clozapine an antipsychotic agent that exerts hardly any extrapyramidal side-effects at clinical efficacious doses. Some previous receptor occupancy studies reported preferential extrastriatal D2/3 receptor (D2/3R)-binding properties of second-generation antipsychotics and suggested this as possible reason for improved tolerability. This positron emission tomography (PET) i...

BACKGROUND Metabolic symptoms induced by antipsychotic medication have been widely documented but there have been few studies comparing the effect of commonly used atypical antipsychotics on blood glucose and lipids among individuals with first-onset schizophrenia. METHODS A total of 150 patients with first-onset schizophrenia were randomized into three groups and each group was treated with ...

Combining measurements of the monoamine metabolites in the cerebrospinal fluid (CSF) and neuroimaging can increase efficiency of drug discovery for treatment of brain disorders. To address this question, we examined five drug-naïve patients suffering from schizophrenic disorder. Patients were assessed clinically, using the Positive and Negative Syndrome Scale (PANSS): at baseline and then at we...