objective(s):drug delivery through the skin can transfer therapeutic levels of drugs for pharmacological effects. analgesics such as nsaids have gastrointestinal side effects and topical dosage forms of these drugs are mainly preferred, especially for local pains. meloxicam is one of nsaids with no topical form in the market. in this research, we attempted to quantify the skin permeation of a m...

the electrochemical behavior of nifedipine (i), nitrendipine(ii) and their photodegradation products has been studied by employing electrochemical techniques in chloroform and in 1:4 mixture of chloroform-isopropanol using piperidinium perchlorate (ppc) as supporting electrolyte. it has been shown that i and ii undergo in a 4e, 4h+ irreversible reduction reaction, while the reduction product, p...

The objective of the present work was to compare the effects of groups of tin and lead organometallic compounds and their mixtures with amphiphilic quaternary ammonium salts (QAS) on the process of calcium ion desorption from lecithin liposome membranes, as dependent on the properties of the hydrophilic and hydrophobic parts of QAS. In the investigations the method of radioactive labels was app...

Examination of the available joint toxic action data, presented in Section 2.2, reveals that no health effects data are available for the complete mixture, or for ternary or quaternary submixtures. Because suitable data, joint action models, and PBPK models are lacking for the complete mixture, the recommended approach for the exposure-based assessment of joint toxic action of this mixture is t...

Combinational nanomedicine is becoming a topic of much interest in cancer therapy, although its translation into the clinic remains extremely challenging. One of the main obstacles lies in the difficulty to efficiently co-deliver immiscible hydrophilic/hydrophobic drugs into tumor sites. The aim of this study was to develop co-loaded lipid emulsions (LEs) to co-deliver immiscible hydrophilic/hy...

It has been suggested that the evolution of protein complexes is significantly influenced by stochastic, non-adaptive processes. Using ligand binding as a proxy of function, we show that the structure of ligand-binding sites significantly influences the evolution of protein complexes. We show that homomers with multi-chain binding sites (MBSs) evolve new functions slower than monomers or other ...

This work examines the adsorption in single- and multi-solute experiments of antibiotic non-steroidal anti-inflammatory drugs, i.e., ciprofloxacin (CPX), sulfamethoxazole (SMX), ibuprofen (IBU), diclofenac (DCF), onto sugarcane bagasse. The maximum experimental capacities single components CPX, DCF, IBU, SMX, were 0.98, 0.77, 0.61, 0.51 mg/g, respectively, with decreases between 5 28% mixtures,...

The authors report the growth of needle-like high density quaternary Zn0.87Cd0.13Se0.98Te0.02nanotips on oxidized Si(100) substrate. It was found that average length and average diameter of the nanotips were 1.3 μm and 91 nm, respectively. It was also found that the as-grown ZnCdSeTe nanotips exhibit mixture of cubic zinc-blende and hexagonal wurtzite structures. Furthermore, it was found that ...