In previous work, a modified version of the Bayesian information criterion (mBIC) was proposed to locate multiple interacting quantitative trait loci (QTL). Simulation studies and real data analysis demonstrate good properties of the mBIC in situations where the error distribution is approximately normal. However, as with other standard techniques of QTL mapping, the performance of the mBIC str...

4. The best way to get help on the functions and data sets in R (and in R/qtl) is via the html version of the help files. One way to get access to this is to type help.start() This should open a browser with the main help menu. If you then click on Packages→ qtl, you can see all of the available functions and datasets in R/qtl. For example, look at the help file for the function read.cross. An ...

When censored time-to-event data are used to map quantitative trait loci (QTL), the existence of nonsusceptible subjects entails extra challenges. If the heterogeneous susceptibility is ignored or inappropriately handled, we may either fail to detect the responsible genetic factors or find spuriously significant locations. In this article, an interval mapping method based on parametric mixture ...

An approach is presented here for quantitative trait loci (QTL) mapping analysis that allows for QTL x environment (E) interaction across multiple environments, without necessarily increasing the number of parameters. The main distinction of the proposed model is in the chosen way of approximation of the dependence of putative QTL effects on environmental states. We hypothesize that environment...

A general method is proposed for calculating approximate thresholds of interval mapping tests for quantitative trait loci (QTL) detection. Simulation results show that this method, when applied to backcross and F2 populations, gives good approximations and is useful for any situation. Programs which calculate these thresholds for backcross, recombinant inbreds and F2 for any given level and any...

The past decade has seen a proliferation of studies that employ quantitative trait locus (QTL) approaches to diagnose the genetic basis of trait evolution. Advances in molecular techniques and analytical methods have suggested that an exact genetic description of the number and distribution of genes affecting a trait can be obtained. Although this possibility has met with some success in model ...

A novel QSPR development technique is proposed with the aim to combine the advantages of the two methods most frequently applied. A quantitative structure-property relationship (QSPR) is developed using this technique to relate the molecular structures of 645 diverse organic compounds to their vapor pressures at 25 C expressed as logVP. The compounds are encoded with topological, electronic, ge...