Accumulating evidence has highlighted the potential role of long non-coding RNAs (lncRNAs) as biomarkers and therapeutic targets in solid tumors. Here, we elucidated the function and possible molecular mechanisms of lncRNA KCNQ1OT1 in human glioma U87 and U251 cells. Quantitative Real-Time polymerase chain reaction (qRT-PCR) demonstrated that KCNQ1OT1 expression was up-regulated in glioma tissu...

BACKGROUND Deregulated miRNA expression plays a crucial role in carcinogenesis. Recent studies show different mechanisms leading to miRNA deregulation in cancer; however, alterations affecting miRNAs by DNA copy number variations (CNV) remain poorly studied. RESULTS Our integrative analysis including data from high resolution SNPs arrays, mRNA expression arrays, and miRNAs expression profiles...

Ovarian cancer is a gynecological malignant tumor with a high mortality rate among women, owing to metastatic progression and recurrence. Acquisition of invasiveness is accompanied by the loss of epithelial features and a gain of a mesenchymal phenotype, a process known as epithelial-mesenchymal transition (EMT). Transforming growth factor-β (TGF-β) has been implicated in the regulation of EMT....

The FermaT transformation system, based on research carried out over the last sixteen years at Durham University, De Montfort University and Software Migrations Ltd., is an industrial-strength formal transformation engine with many applications in program comprehension and language migration. This paper is a case study which uses automated plus manually-directed transformations and abstractions...

The interpretive-execution facility of Enterprise Systems Architecture/390TM (ESA/390TM) provides an instruction for the execution of virtual machines. This instruction, called START INTERPRETIVE EXECUTION (SIE), was initially created for virtualizing either System/370m or 370-XA architectures and was used later for virtualizing ESA/370' and ESA/390 architectures. SIE has evolved to provide cap...

The Enterprise Systems Architecturel370" provides a significant step in the IBM System/370 evolution by providing new capabilities for virtual addressing and program linkage across multiple address spaces. This paper reviews the evolution that led to this advance and illuminates the goals, such as eliminating growth constraints and improving security, integrity, reliability, and performance, th...