Optically active six-membered rings such as cyclohexanes and piperidines play an important role as biologically active building blocks and key intermediates in organic chemistry. Catalytic asymmetric hydrogenation of aromatic and heteroaromatic compounds is one of themost straightforward routes for the formation of these saturated or partially saturated molecules. Recently, tremendous progress ...

Protozoan parasites of the Leishmania genus express the metabolic machinery to synthesize pyrimidine nucleotides via both de novo and salvage pathways. To evaluate the relative contributions of pyrimidine biosynthesis and salvage to pyrimidine homeostasis in both life cycle stages of Leishmania donovani, individual mutant lines deficient in either carbamoyl phosphate synthetase (CPS), the first...

1. Abstract 2. Introduction 3. Purine and pyrimidine metabolism during somatic embryogenesis 3.1. Maintenance of embryogenic tissue 3.1.1. Purine metabolism during maintenance of embryogenic tissue 3.1.2. Pyrimidine metabolism during maintenance of embryogenic tissue 3.2. Development of somatic embryos 3.2.1. Purine metabolism during development of somatic embryos 3.2.2. Pyrimidine metabolism d...

While elemental sulfur has been largely used as oxidant or sulfurating agent, its role a catalyst not developed. We report here catalytic activity in the oxidative condensation of o-phenylenediamines with acetophenones DMSO to provide quinoxalines. The method was also extended α-tetralones, propiophenones (R=Me) well higher homologues (R=Et, n-Pr) place acetophenones, leading wide range naphtho...

easily synthesized1-methyl-3-(2-oxyethyl)-1h-imidazol-3-ium-borate sulfonic acid {[moei]-bsa} as a novel catalyst efficiently promoted the synthesis of quinoxaline derivatives via condensation of various diamines with 1,2-dicarbonyl compounds at room temperature conditions in ethanol. this research provides a new method for the synthesis of quinoxalines in good to excellent yields with little c...

Aim: To study the effect of new synthesized pyrimidine derivatives on growth Mycobacterium lufu ( M. ) and tuberculosis when cultivated Shkolnikova’s medium. Materials methods. The objects research were 6 samples - 5-(arylmethylidene)-2,4,6-pyrimidine-2,4,6(1 H ,3 ,5 )-trions under laboratory codes TAG1, TAG2, TAG3, TAG4, TAG5, TAG6 7 5-(getarylmethylidene)-2,4,6-pyrimidine-2,4,6(1 , 3 5 TAG7, ...