نتایج جستجو برای: pyridoxal 5
تعداد نتایج: 1216994 فیلتر نتایج به سال:
Treatment of 1 microM wheat-germ aspartate transcarbamoylase with 1 mM-pyridoxal 5'-phosphate caused a rapid loss of activity, concomitant with the formation of a Schiff base. Complete loss of activity occurred within 10 min when the Schiff base was reduced with a 100-fold excess of NaBH4. Concomitantly, one amino group per chain was modified. No further residues were modified in the ensuing 30...
Previous studies in vivo and with isolated perfused rat livers have suggested that the deleterious effect of ethanol on hepatic pyridoxal 5'-phosphate metabolism is mediated by acetaldehyde. Inasmuch as acetaldehyde has no effect on the synthesis of pyridoxal phosphate, it has also been postulated that acetaldehyde accelerates pyridoxal phosphate degradation by displacing this coenzyme from bin...
The interaction of a variety of pyridoxal analogues with glutamate decarboxylase and aspartate aminotransferase has been studied. Pyridoxal phosphate N-oxide, N-methylpyridoxal phosphate, 3-0-methylpyridoxal phosphate, 4-de(formyl)-4-vinyl pyridoxal phosphate, and pyridoxal analogues which contain modified substituents in position 5 (CH2CHrOPOsHL, CH(CHB)OPOIH2, CHVPOBHL, and CHICH,COOH) are bo...
Vitamin B6 derivatives protect the retinal neurons from excitotoxic injury in vitro. However, their in vivo role in a process involving excitotoxicity, such as ischemia, remains unknown. We studied potential protective effects of pyridoxal 5'-phosphate (PLP) and pyridoxal hydrochloride (pyridoxal) on the retinal neurons in a monkey model of transient global ischemia. Daily intravenous injection...
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