IL: interleukin PAPA: pyogenic arthritis, pyoderma gangrenosum, and acne PASH: pyoderma gangrenosum, acne, and suppurative hidradenitis PG: pyoderma gangrenosum TNF: tumor necrosis factor UC: ulcerative colitis INTRODUCTION Pyoderma gangrenosum (PG) is a rare, inflammatory, and necrotizing disease that belongs to the group of neutrophilic dermatosis. The pathogenesis of PG remains unknown. In t...

we report an unusual case of co?infection of invasive pulmonary aspergillosis (ipa) and fusarial skin infection in a patient with classic pyoderma gangrenosum with unknown causes, which were previously controlled with oral prednisolone, cyclosporine. the diagnosis was made on direct microscopy and culture of endobronchial washing, bronchoalveolar lavage and skin lesion biopsy. the treatment fai...

In five patients with inflammatory bowel disease (three with ulcerative colitis, two with Crohn's disease), pyoderma gangrenosum developed on a lower extremity at the site of trauma. In these subjects, the pyoderma was not clearly correlated with disease activity.

PAPASH syndrome is a rare autoinflammatory consisting of four essential components: pyogenic arthritis (PA), pyoderma gangrenosum (PG), acne (A), and suppurative hidradenitis (SH). The true etiology unknown, yet genetic analysis has shown associations with PSTPIP1 mutations, which ultimately lead to elevations in interleukin-1 activity. Herein, we report case painful ulcers 47-year-old Syrian m...

We herein report a severe case of pyoderma gangrenosum occurring in a burn patient and discuss the possibility of occult complications of this pathological state in daily treatment.

BACKGROUND Pyoderma gangrenosum is an ulcerative condition that may be associated with inflammatory bowel disease or inflammatory arthritis. In addition to local wound care, management often includes the use of systemic corticosteroids or systemically administered immunomodulatory agents. OBSERVATIONS We retrospectively analyzed 7 patients with pyoderma gangrenosum who were treated with mycop...

BACKGROUND Pyoderma gangrenosum is an inflammatory neutrophilic dermatosis characterized by painful cutaneous ulcerations and often associated with systemic inflammatory and neoplastic diseases. Here we report the first case of pyoderma gangrenosum in a patient with refractory celiac disease. CASE PRESENTATION A 52-year-old woman with a previously diagnosed refractory celiac disease resistant...

Severe. lifelong, unresolv;ng pyoderma gangrenosum occurs in association with recurrent episodes of sterile pyoarthrosis and the presence of a serum factor (called "streaking leukocyte factor") (1) responsible for enhancing random migration of purified human neutrophils and mononuclear leukocytes in vitro. Pyoderma gangrcnosum is only one feature of this unusual disease. Minor trauma of any sor...