In many organisms, including plants, nucleic acid bases and derivatives such as caffeine are transported across the plasma membrane. Cytokinins, important hormones structurally related to adenine, are produced mainly in root apices, from where they are translocated to shoots to control a multitude of physiological processes. Complementation of a yeast mutant deficient in adenine uptake (fcy2) w...

Abstract Amino acid decorated imidazole, pyrimidine and purine derivatives, resembling analogues of peptide nucleic acid's building blocks, have been synthesized by a three‐way multicomponent chemistry diaminomaleonitrile, one the most studied chemical precursors in prebiotic chemistry. The regioselectivity reaction between trimethyl orthoacetate selected panel α‐amino acids, was controlled ene...

Animal agricultural production systems are major sources of nonpoint pollution affecting quality of water sources. Nitrogen has been identified as the foremost source of nonpoint water pollution  and the potential negative impacts of N have become an area of public concern. protein degradation from feed ingredients is an important factorinfluencing AA supply to the duodenum. Ruminal proteolysis...

Animal agricultural production systems are major sources of nonpoint pollution affecting quality of water sources. Nitrogen has been identified as the foremost source of nonpoint water pollution  and the potential negative impacts of N have become an area of public concern. protein degradation from feed ingredients is an important factorinfluencing AA supply to the duodenum. Ruminal proteolysis...

Svihla, G. (Argonne National Laboratory, Argonne, Ill.), J. L. Dainko, and F. Schlenk. Ultraviolet microscopy of purine compounds in the yeast vacuole. J. Bacteriol. 85:399-409. 1962.-Yeast cells (Candida utilis and Saccharomyces cerevisiae) suspended in nitrogen-free medium were exposed to various ultraviolet-absorbing biological compounds, particularly nucleic acid constituents. Ultraviolet p...

Triplexes with a gap in the purine strand have been shown to bind adenosine or guanosine derivatives through a combination of Watson-Crick and Hoogsteen base pairing. Rigidifying the binding site should be advantageous for affinity. Here we report that clamps delimiting the binding site have a modest effect on affinity, while bridging the gap of the purine strand can strongly increase affinity ...

This research was conducted to estimate the amount of microbial protein synthesis in Iranian buffaloes' rumen. Four male swamp buffaloes with average live body weight of 140±10 kg were used in this study. Four diets of 0 (control diet, 100% forage), 15, 30 and 45% concentrate in a 4 × 4 Latin Square were tested. The results indicated that by increasing the concentrate level in the diet of swamp...

Deaminases are enzymes that catalyze the hydrolysis of amino groups of nucleosides or their bases. Because these enzymes play important roles in nucleotide metabolism, they are relevant targets in anticancer and antibacterial therapies. Mammalian deaminases are commercially available but the use of bacterial whole cells, especially as biocatalysts, is continuously growing because of their econo...

The alkylation of purines which is generally carried out after anion formation by treatment with a base and alkyl halide complicated in the best cases, mixtures N-alkylated compounds are obtained. Purine derivatives can be acquired from at N-7 N-9. In this work, reaction conditions have been optimized to obtain products N-9 regioselectively. Different bases tried tetrabutylammonium hydroxide ha...