Drug efflux pumps play a key role in drug resistance and also serve other functions in bacteria. There has been a growing list of multidrug and drug-specific efflux pumps characterized from bacteria of human, animal, plant and environmental origins. These pumps are mostly encoded on the chromosome, although they can also be plasmid-encoded. A previous article in this journal provided a comprehe...

Thermoacoustic-Stirling hybrid engines and feedback pulse tube refrigerators can utilize jet pumps to suppress streaming that would otherwise cause large heat leaks and reduced efficiency. It is desirable to use jet pumps to suppress streaming because they do not introduce moving parts such as bellows or membranes. In most cases, this form of streaming suppression works reliably. However, in so...

The role of continuous subcutaneous insulin infusion (insulin pumps) has become increasingly important in diabetes management, and many different types of these systems are currently available. This exploratory study focused on the reported heating issues that lithium-ion battery-powered pumps may have during charging compared with battery-operated pumps. It was found that pump temperature incr...

There are various delivery devices available for insulin like syringes, pens, and insulin pumps. Syringes have drawbacks like dosage errors and pain. Insulin pumps can be useful to mimic the physiological insulin secretion. Though the insulin pumps are launched in India a decade ago, they are not popular due to high price and thus there is limited experience and queries with its use. Use of ins...

Active efflux of drugs mediated by efflux pumps that confer drug resistance is one of the mechanisms developed by bacteria to counter the adverse effects of antibiotics and chemicals. To understand these efflux mechanisms in Mycobacterium tuberculosis, we generated knockout (KO) mutants of four efflux pumps of the pathogen belonging to different classes. We measured the MICs and kill values of ...

Cooper pair pumping is a coherent process. We derive a general expression for the adiabatic pumped charge in superconducting nanocircuits in the presence of level degeneracy and relate it to non-Abelian holonomies of Wilczek and Zee. We discuss an experimental system where the non-Abelian structure of the adiabatic evolution manifests in the pumped charge.

From the $Department of Pediatrics/Biochemistry, Vanderbilt University, Nashville, Tennessee 37232, the **Department of Molecular Biology, Vanderbilt University, Nashville, Tennessee 37235, the 11 Veterans Administration Medical Center, Boise, Idaho 83702, the Department of Medicine, University of Washington, Seattle, Washington 98185, and the IIRoswell Park Memorial Institute, Buffalo, New Yor...

We have established semiclassical kinetic equations for various spin correlated pumping phenomena incorporating adiabatic spin rotation in wave functions. We employ this technique to study topological pumps and illustrate spin pumping in a few models where various spin configurations or topological motors drive adiabatic pumps. In the Rashba model we find that a topological spin pump is driven ...

Resistance-Nodulation-Division (RND) efflux pumps are one of the most important determinants of multidrug resistance (MDR) in Gram-negative bacteria. With an ever increasing number of Gram-negative clinical isolates exhibiting MDR phenotypes as a result of the activity of RND pumps, it is clear that the design of novel effective clinical strategies against such pathogens must be grounded in a b...