نتایج جستجو برای: puma

تعداد نتایج: 2161  

2015
Emanuela Papaianni Souhayla El Maadidi Andrea Schejtman Simon Neumann Ulrich Maurer Francesca Marino-Merlo Antonio Mastino Christoph Borner Dhyan Chandra

Viruses can trigger apoptosis of infected host cells if not counteracted by cellular or viral anti-apoptotic proteins. These protective proteins either inhibit the activation of caspases or they act as Bcl-2 homologs to prevent Bax/Bak-mediated outer mitochondrial membrane permeabilization (MOMP). The exact mechanism by which viruses trigger MOMP has however remained enigmatic. Here we use two ...

2016
Haidan Liu Wei Li Xinfang Yu Feng Gao Zhi Duan Xiaolong Ma Shiming Tan Yunchang Yuan Lijun Liu Jian Wang Xinmin Zhou Yifeng Yang

Polycomb group (PcG) proteins are highly conserved epigenetic effectors that maintain the silenced state of genes. EZH2 is the catalytic core and one of the most important components of the polycomb repressive complex 2 (PRC2). In non-small cell lung cancer (NSCLC) cells and primary lung tumors, we found that PRC2 components, including EZH2, are overexpressed. High levels of EZH2 protein were a...

2016
Shahryar Khoshtinat Nikkhoi Hedieh Heydarzadeh Saeed Ranjbar Fatemeh Salimi Masoud Aghaeifard Seyed Moayed Alavian Azadeh Reshadmanesh

BACKGROUND Cancerous cells proliferate as fast as possible without a proper surveillance system. This rapid cell division leads to enormous mutation rates, which help a tumor establish. OBJECTIVES This study evaluated the potential of inducing apoptosis using Noxa and Puma in a hepatocarcinoma cell line. METHODS The current study generated two recombinant lentiviruses, pLEX-GCN and pLEX-GCP...

Journal: :The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2012
Taketoshi Wakabayashi Jun Kosaka Tetsuji Mori Hisao Yamada

During development of the nervous system, large numbers of neurons are overproduced and then eliminated by programmed cell death. Puma is a BH3-only protein that is reported to be involved in the initiation of developmental programmed cell death in rodent retinal neurons. The expression and cellular localization of Puma in retinal tissues during development are not, however, well known. Here th...

2005
Miriam Erlacher Ewa M. Michalak Priscilla N. Kelly Verena Labi Harald Niederegger Leigh Coultas Jerry M. Adams Andreas Strasser Andreas Villunger

Numerous p53 target genes have been implicated in DNA damage-induced apoptosis signaling, but pro-apoptotic Bcl-2 family members of the BH3-only subgroup appear to play the critical initiating role. In various types of cultured cells, three BH3-only proteins, namely Puma, Noxa and Bim, have been shown to initiate p53-dependent as well as p53-independent apoptosis in response to DNA damage, trea...

Journal: :The Journal of biological chemistry 2004
Gerry Melino Francesca Bernassola Marco Ranalli Karen Yee Wei Xing Zong Marco Corazzari Richard A Knight Doug R Green Craig Thompson Karen H Vousden

p73, an important developmental gene, shares a high sequence homology with p53 and induces both G(1) cell cycle arrest and apoptosis. However, the molecular mechanisms through which p73 induces apoptosis are unclear. We found that p73-induced apoptosis is mediated by PUMA (p53 up-regulated modulator of apoptosis) induction, which, in turn, causes Bax mitochondrial translocation and cytochrome c...

2017
María de Las Mercedes Guerisoli Estela Luengos Vidal Marcello Franchini Nicolás Caruso Emma Beatriz Casanave Mauro Lucherini

Livestock predation is one of the major causes of conflicts between humans and pumas (Puma concolor). Using data from interviews with ranchers and kill-site inspections, we characterized puma-livestock conflicts in Villarino and Patagones counties of central Argentinean rangelands. Depredation was considered the major cause of livestock losses, and puma attacks were reported in 46.6% and 35.4% ...

2017
Tae-Gyun Woo Min-Ho Yoon Shin-Deok Hong Jiyun Choi Nam-Chul Ha Hokeun Sun Bum-Joon Park

Hyper-activation of PAK1 (p21-activated kinase 1) is frequently observed in human cancer and speculated as a target of novel anti-tumor drug. In previous, we also showed that PAK1 is highly activated in the Smad4-deficient condition and suppresses PUMA (p53 upregulated modulator of apoptosis) through direct binding and phosphorylation. On the basis of this result, we have tried to find novel PA...

Journal: :Blood 2007
Maria Ekoff Thomas Kaufmann Maria Engström Noboru Motoyama Andreas Villunger Jan-Ingvar Jönsson Andreas Strasser Gunnar Nilsson

Mast cells play critical roles in the regulation of inflammation. One characteristic feature of mast cells is their relatively long lifespan in vivo. Members of the Bcl-2 protein family are regulators of cell survival and apoptosis, where the BH3-only proteins are critical proapoptotic proteins. In this study we investigated the role of the BH3-only proteins Noxa, Bad, Bim, Bmf, Bid, and Puma i...

Journal: :Acta biochimica et biophysica Sinica 2014
Xiali Zhang Shuo Tu Yibing Wang Baohua Xu Fusheng Wan

Taurine (Tau) has been shown to possess cancer therapeutic effect through induction of apoptosis, while the underlying molecular mechanism of its anti-cancer effect is not well understood. PUMA (p53-upregulated modulator of apoptosis) plays an important role in the process of apoptosis induction in a variety of human tumor cells in both p53-dependent and -independent manners. However, whether P...

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