BACKGROUND BJUT-II VAD is a novel left ventricular assist device (LVADs), directly implanted into the ascending aorta. The pulsatile support mode is proposed to achieve better unloading performance than constant speed mode. However, the hemodynamic effects of this support mode on the aorta are still unclear. The aim of this study was to clarify the hemodynamic effects BJUT-II VAD under pulsatil...

Type 2 diabetes mellitus (T2D) is a significant global public health problem that has seen substantial increase in the number of affected individuals recent decades. In murine model T2D (db/db), we found several abnormalities, including aberrant intracellular calcium concentration ([Ca2+]i), decreased glucose transport, increased production reactive oxygen species (ROS), elevated levels pro-inf...

The aim of this study was to investigate the development of pulsatile GnRH secretion by GnRH neurones in primary cultures of olfactory placodes from ovine embryos. Culture medium was collected every 10 min for 8 h to detect pulsatile secretion. In the first experiment, pulsatile secretion was studied in two different sets of cultures after 17 and 24 days in vitro. In the second experiment, a se...

he advent of cardiopulmonary bypass (CPB) has enabled cardiovascular surgeons to perform complex, life-saving procedures with relative ease while protecting end-organ function. Altering the normal pulsatile blood flow to non-pulsatile continuous flow has raised concerns over potential detrimental hemodynamic and physiologic consequences. Concerns over long-term non-pulsatile flow drove the desi...

Fatigue resistance of nitinol stents implanted in femoropopliteal arteries is a critical issue because their harsh biomechanical environment. Limb flexions due to daily walk expose the and, subsequently, large cyclic deformations, which may lead fatigue failure smart self-expandable stents. For first time, this paper utilised up-to-date measurements walk-induced motion human artery investigate ...

BACKGROUND For blood purification systems using a semipermeable membrane, the convective mass transfer by ultrafiltration plays an important role in toxin removal. The increase in the ultrafiltration rate can improve the toxin removal efficiency of the device, ultimately reducing treatment time and cost. In this study, we assessed the effects of pulsatile flow on the efficiency of the convectiv...

transradial coronary angiography has been known as an alternative to the transfemoral approach with fewer serious complications. radial artery pseudoaneurysms present as a rare complication of transradial catheterization. although some methods have been applied for the obliteration of pseudoaneurysms, the use of radial bands such as the tr band ® (terumo medical corporation, somerset, nj) is a ...

BACKGROUND Vascular smooth muscle cell proliferation is the key event of coronary artery disease. Mechanical forces, in particular, pulsatile stretch and platelet-derived growth factor, may play an important role. METHODS AND RESULTS Vascular smooth muscle cells were cultured from the media of human left descending coronary arteries obtained from organ donors using the explant method. To stud...

The role of the endothelium in regulating transmural fluid filtration into the artery wall under pulsatile pressure and the effects of changes in pulsatile frequency on filtration have received little attention. Previous experiments (Alberding JP, Baldwin AL, Barton JK, and Wiley E. Am J Physiol Heart Circ Physiol 286: H1827-H1835, 2004) demonstrated significantly increased filtration after ini...

The rostral ventrolateral medulla (RVLM) is considered a major center for the regulation of sympathetic and cardiovascular activities. Several clinical studies have indicated a possible causal relationship between neurovascular contact of the left RVLM and essential hypertension, and some investigators have suggested that the left RVLM is more sensitive to pulsatile compression than the right R...