Elevated plasma free fatty acids (FFA) induce skeletal muscle insulin resistance and impair endothelial function. The aim of this study was to characterize the acute hemodynamic effects of FFA in the eye and skin. A triglyceride (Intralipid 20%, 1.5 ml/min)/heparin (bolus: 200 IU; constant infusion rate: 0.2 IU. kg(-1). min(-1)) emulsion or placebo was administered to 10 healthy subjects. Measu...

We present an analysis of the accuracy of the lattice Boltzmann BGK (LBGK) method in simulating pulsatile blood flow in a model of the Human Abdominal Aorta. The flow is driven by a systolic pressure cycle. As a benchmark, we consider fully developed pulsatile flow in a straight tube. We compare velocity profiles and shear stress to the analytical Womersley solutions. The accuracy of the bounce...

With an aim to investigate the effect of externally imposed body acceleration on two dimensional,pulsatile blood flow through a stenosed artery is under consideration in this article. The blood flow has been assumed to be non-linear, incompressible and fully developed. The artery is assumed to be an elastic cylindrical tube and the geometry of the stenosis considered as time dependent, and a co...

CFD modelling is a powerful, but largely under-utilised tool for biomedical applications. In particular, it has great potential for helping us better understand the mechanisms responsible for cardiovascular disease such as artherosclerosis and thrombi formation. Flow behaviour in blood vessels has been shown to depend strongly on features of the local geometry such as branching, bending, and re...

In this research, we present a new designed experimental setup for study of characteristics of pulsatile flow in elastic tubes, aiming to simulate arterial blood flow. This system includes four major components: (1) a pulsatile pump producing original arterial flow, (2) an elastic element to simulate coupling of the heart with the arterial system, (3) an elastic tube with mechanical characteris...

Pulsatile Flow Analysis of the Femoral Artery To the Editor: We read with great interest the article, “Pulse Pressure Amplification, Arterial Stiffness, and Peripheral Wave Reflection Determine Pulsatile Flow Waveform of the Femoral Artery” by Hashimoto et al,1 studying the correlation between reverse diastolic blood flow and increased arterial stiffness in the femoral artery. The authors empha...

The objective of this study was to compare the effects of pulsatile and nonpulsatile extracorporeal membrane oxygenation (ECMO) on hemodynamic energy and systemic microcirculation in an acute cardiac failure model in piglets. Fourteen piglets with a mean body weight of 6.08 ± 0.86 kg were divided into pulsatile (N = 7) and nonpulsatile (N = 7) ECMO groups. The experimental ECMO circuit consiste...

BACKGROUND There is evidence that altered ocular blood flow is involved in the development and progression of diabetic retinopathy. However, the nature of these perfusion abnormalities is still a matter of controversy. Ocular haemodynamics were characterised with two recently introduced methods. METHODS The cross sectional study was performed in 59 patients with type 1 diabetes with a diabete...