Pulsatile growth hormone (GH) secretion putatively reflects integrated regulation by GH-releasing hormone (GHRH), somatostatin (SST), and GH-releasing peptide (GHRP). GHRH and SST secretion is itself pulsatile. However, how GHRH and SST pulses act along with GHRP to jointly determine pulsatile GH secretion is unclear. Moreover, how testosterone (T) modulates such interactions is unknown. These ...

____________ _ (}. Extra-Corpor. Techno/. 20[ 1]: p. 24-29, 60 references, Spring 1988) Pulsatile perfusion has been a topic of great controversy for many years. This paper reviews historical aspects of pulsatile perfusion, as well as current and conceptual aspects of pulsatile perfusion. The positive and negative points of pulsatile perfusion are discussed so the reader may draw conclusions in...

Insulin is secreted as discrete insulin secretory bursts at ~5-min intervals into the hepatic portal vein, these pulses being attenuated early in the development of type 1 and type 2 diabetes mellitus (T2DM). Intraportal insulin infusions (pulsatile, constant, or reproducing that in T2DM) indicated that the pattern of pulsatile insulin secretion delivered via the portal vein is important for he...

Jung et al.34 (2007) randomly allocated 13 Yorkshire pigs to two groups for pulsatile (twin pulse pump, n=7) versus non-pulsatile (biopump, n=6) VAD treatment after electrically induced ventricular fibrillation and investigated the flow in the left coronary artery. After 20, 40, 60, 80, 100 and 120 min, they measured mean coronary flows of 0.77±0.3, 0.76±0.19, 0.95±0.23, 0.86±0.23, 1.00±0.24 an...

A cardinal physiological feature of anterior pituitary hormone secretion is its pulsatile mode of signalling to remote target tissues. The pulsatile release of anterior pituitary hormones is orchestrated by episodic neuronal activation of hypothalamic control centres, which release relevant effector molecules intermittently. The anterior pituitary gland in turn secretes hormones in ultradian bu...

Synchrotron X-ray imaging technique has been used to investigate biofluid flows in a non-destructive manner. This study aims to investigate the feasibility of the X-ray PIV technique with CO2 microbubbles as flow tracer for measurement of pulsatile blood flows under in vivo conditions. The traceability of CO2 microbubbles in a pulsatile flow was demonstrated through in vitro experiment. A rat e...

The shortage of donor hearts and the physiological impact of pulsatile perfusion have driven technical innovation research efforts to create a positive displacement total artificial heart that can produce pulsatile flow and has a reasonable size for long-term assist in chronic heart failure. Such a product is the Scandinavian Real Heart 8 (SRH8); a new pulsatile total artificial heart. We here ...

This paper reports a case of spontaneous indirect carotid cavernous fistula that presented with pulsatile tinnitus, left-sided temporal headache and left-sided ptosis. The pulsatile tinnitus, its aetiology and investigation are discussed. The importance of pulsatile tinnitus is highlighted, with a discussion of carotid-cavernous fistulas. This case illustrates that clinically silent cavernous s...

In this study, two existing mathematical cardiovascular models, a non-pulsatile global model and a simplified pulsatile left heart model were investigated, modified and combined. A global lumped compartment cardiovascular model was developed that could predict the pressures in the systemic and pulmonary circulation, and specifically the pulsatile pressures in the the finger arteries where real-...

Although pulsatile tinnitus can be audible, objective demonstration of this heartbeat-synchronous sound has rarely been successful. We report a rare case of pulsatile tinnitus in a 44-yr-old female patient, which was induced by a large mastoid emissary vein (MEV) and objectively documented by Doppler sonography of the left posterior auricular region. The tinnitus was intermittent and the patien...