Current radiation therapy (RT) planning for limiting lung toxicity assumes a uniform distribution of lung function with little consideration to the spatial and temporal pattern of lung function. Establishment of relationships between radiation dose and pulmonary function change can help predict and reduce the RT-induced pulmonary toxicity. Baseline measurement uncertainty of pulmonary function ...

Preventing tissue-factor-(TF-) mediated systemic coagulopathy improves outcome in models of sepsis. Preventing TF-mediated pulmonary coagulopathy could attenuate ventilator-induced lung injury (VILI). We investigated the effect of relative TF deficiency on pulmonary coagulopathy and inflammation in a murine model of VILI. Heterozygous TF knockout (TF(+/-)) mice and their wild-type (TF(+/+)) lit...

COPD and asthmatic patients use a substantial proportion of mechanical ventilation in the ICU, and their overall mortality with ventilatory support can be significant. From the pathophysiological standpoint, they have increased airway resistance, pulmonary hyperinflation, and high pulmonary dead space, leading to increased work of breathing. If ventilatory demand exceeds work output of the resp...

ventilation for acute exacerbations of chronic obstructive pulmonary disease. N Engl J Med 1995;28:817e22. 4. Man WD-C, Polkey MI, Donaldson N, et al. Community pulmonary rehabilitation after hospitalisation for acute exacerbations of chronic obstructive pulmonary disease: randomised controlled study. BMJ 2004;329:1209. 5. Schönhofer B. Non-invasive positive pressure ventilation in patients wit...

ventilation for acute exacerbations of chronic obstructive pulmonary disease. N Engl J Med 1995;28:817e22. 4. Man WD-C, Polkey MI, Donaldson N, et al. Community pulmonary rehabilitation after hospitalisation for acute exacerbations of chronic obstructive pulmonary disease: randomised controlled study. BMJ 2004;329:1209. 5. Schönhofer B. Non-invasive positive pressure ventilation in patients wit...

Introduction: Pulmonary tuberculosis is ranked the second health problem in world, including Indonesia with reasonably high mortality rates. This study examined association between ventilation, physical condition, and prevalence of pulmonary working area Sragen Primary Healthcare Center. Methods: used a case-control design purposive sampling to select 40 patients positive smear as case group su...

Banerjee, C. K., Girling, D. J., and Wigglesworth, J. S. (1972). Archives of Disease in Childhood, 47, 509. Pulmonary fibroplasia in newborn babies treated with oxygen and artificial ventilation. A retrospective clinicopathological study was carried out on newborn babies who had died over a 5-year period, had received oxygen therapy, and had lived for 48 hours or longer. 23 of 81 babies had pul...

BACKGROUND In anesthetized patients undergoing surgery, the role of lung-protective ventilation with lower tidal volumes is unclear. We performed a meta-analysis of randomized controlled trials (RCTs) to evaluate the effect of this ventilation strategy on postoperative outcomes. METHODS We searched electronic databases from inception through September 2014. We included RCTs that compared prot...

BACKGROUND This meta-analysis evaluated the effect of noninvasive, positive pressure ventilation on severe, stable chronic obstructive pulmonary disease (COPD). METHODS PUBMED, CNKI, Wanfang, EMBASE and the Cochrane trials databases were searched. Randomized controlled trials of patients with severe, stable COPD and receiving noninvasive positive pressure ventilation, compared with sham venti...

Acute exacerbation of chronic obstructive pulmonary disease (COPD) requiring invasive mechanical ventilation (IMV) is associated with a very poor prognosis. Therefore noninvasive mechanical ventilation (NIV) with avoidance of endotracheal intubation should be preferred. However, NIV can fail and result in severe respiratory acidosis. If IMV becomes mandatory, the development of pulmonary dynami...