Lipoxin A4 as a possible mediator of the beneficial actions of phosphodiesterase-5 enzyme inhibitors Undurti N. Das Phosphodiesterase-5 enzyme inhibitors (PDE-5-Is) such as sildenafil, vardenafil and tadalafil are used in the treatment of male erectile dys-function (ED). Their beneficial action can be attributed to an increase in the intracellular cGMP level due to inhibition of PDE-5 and conse...

BACKGROUND Tissue factor (TF) is the initiation factor of the extrinsic coagulation pathway, and plays a critical role in the process of thrombosis. This study aimed to investigate the expression of TF and to explore their clinical effect on the pulmonary artery after acute pulmonary thromboembolism. METHODS Thirty-four Japanese white rabbits (Level II animals) supplied by Tianjin Medical Uni...

Systemic activation of coagulation and pulmonary thrombo-inflammation with local vascular damage caused by SARS-CoV-2 infection increases the risk developing thromboembolic complications: stroke, arterial thrombosis (pulmonary thromboembolism) deep vein thrombosis. Myopericarditis may occurs in COVID-19 patients as part or after onset respiratory symptoms. Minor pericardial effusions up to 1 cm...

The purpose of this EP Wire was to assess the indications, techniques, and outcomes of left atrial appendage occlusion (LAAO) in Europe. Thirty-three European centres, all members of the European Heart Rhythm Association electrophysiology (EP) research network, responded to this survey by completing the questionnaire. The major indication for LAAO (94%) was the prevention of stroke in patients ...

AIMS To assess the relation between the atrial fibrillation (AF) subtype and thrombo-embolic events. METHODS AND RESULTS The observational Euro Heart Survey on AF (2003-04) enrolled 1509 paroxysmal, 1109 persistent, and 1515 permanent AF patients, according to the 2001 American College of Cardiology, American Heart Association, and the European Society of Cardiology guidelines definitions. A ...