The present study was undertaken to evaluate the role of propofol in altering pentylenetetrazol induced seizure threshold in rats. Total 42 Wistar rats were used to evaluate different parameters (onset of action, duration of seizure, seizure severity score and number of seizure) following propofol injection. The present results showed that there was significant reduction in the time required fo...

There is some evidence that epileptic seizures could be induced or increased by 5-hydroxytryptamine (5-HT) attenuation, while augmentation of serotonin functions within the brain (e.g. by SSRIs) has been reported to be anticonvulsant. This study was performed to determine the effect of selective 5-HT(3) channel/receptor antagonist granisetron and agonist SR57227 hydrochloride on the pentylenete...

The purpose of this study was to determine if aversive effects of alcohol withdrawal could be detected in mice using the place conditioning procedure and whether the GABA(A) receptor antagonist, pentylenetetrazol (PTZ), would increase the aversive effects of alcohol withdrawal and increase the probability of detecting conditioned place aversion. Subjects were alcohol-naïve mice from a specific ...

Piperacillin-tazobactam (PTZ) is frequently used as empirical and targeted therapy for Gram-negative sepsis. Time-dependent killing properties of PTZ support the use of extended-infusion (EI) dosing; however, studies have shown inconsistent benefits of EI PTZ treatment on clinical outcomes. We performed a retrospective cohort study of adult patients who received EI PTZ treatment and historical ...

We have designed and synthesized a pair of highly asymmetric D-aA-D′ type pyridyl-sulfonyl based isomers comprising phenothiazine (PTZ) carbazole (Cz) donor units, which are able to emit thermally activated delayed fluorescence. PTZ-pS4-Py-2Cz PTZ-mS4-Py-2Cz both possess spatial separation HOMO/LUMO on the acceptor moieties, resulting in small calculated singlet–triplet energy gaps (~0.25 eV). ...

Aim: The current study investigated the effects of artemisinin on heart and lung tissue against pentylenetetrazol-induced seizures in mice. For this purpose, malondialdehyde (MDA), advanced oxidation protein products (AOPP), Catalase (CAT), glutathione (GSH), peroxidase (GSH-Px) levels were evaluated both homogenates.Material Method: Swiss albino male mice (n=42) used experiment. Animals divide...

Nitric oxide (NO) is known to be a neuromodulator with dual proconvulsive and anticonvul- sive action. Valeriana officinalis (VAL) was previously believed antiepileptic, but today as sedative sleep regulator. Seizures may associated abnormal electrocardio- graphic changes cardiac dysfunction arising from epilepsy related neuronal nitric (nNO). This study aimed investigate the effects of synthas...

Thyme with the scientific moniker of Thymus vulgaris has been used in traditional medicine for treatment respiratory and gastrointestinal disease. Its extract also adopted to treat epilepsy other central nervous system (CNS) disorders. To evaluate effect T. (TVE), experimental model memory impairment caused by seizures was performed rats. Seizures Wistar rats (200-250 g) were induced a challeng...

We have investigated excited-state electron transfer in a donor-bridge-acceptor complex containing phenothiazine (PTZ) linked via tris(meta-phenylene-ethynylene) to a tricarbonyl(bipyridine)(pyridine)Re(I) unit. Time-resolved luminescence experiments reveal two excited-state (*Re) decay regimes, a multiexponential component with a mean lifetime of 2.7 ns and a longer monoexponential component o...