Couplings between protons, whether scalar or dipolar, provide a wealth of structural information. Unfortunately, the high number of (1)H-(1)H couplings gives rise to complex multiplets and severe overlap in crowded spectra, greatly complicating their measurement. Many different methods exist for disentangling couplings, but none approaches optimum resolution. Here, we present a general new 2D J...

Psychedelic substances are used for clinical applications (e.g., treatment of addictions, anxiety and depression) as well as an investigative tool in neuroscientific research. Recently it has been proposed that the psychedelic phenomenon stems from the brain reaching an increased entropic state. In this paper, we use the predictive coding framework to formalize the idea of an entropic brain. We...

In the mid-1960s, legislation in the United States instituted a prohibition on the use of psychedelic drugs, not only the supposedly alarming use by hippies, intellectuals, beatniks, college students, etc., but also use by scientific researchers and mental health professionals. The ban on practically all research and therapy was soon forced upon the rest of the world by international treaties a...

Abstract A renaissance is underway as research studies are substantiating psychotherapeutic and physiological benefits of psychedelic medicines, along with advancements towards legalization, expansion professional training programs a renewed cultural recognition the healing qualities medicines. Pending legislation, cadre trained psychotherapists poised to apply their expertise for those who mig...

Growing research on potential therapeutic applications of highly restricted Schedule I hallucinogens, including the ‘classic psychedelic’ psilocybin, and entactogen 3,4-Methylenedioxymethamphet...

Psychedelic use is generally considered safe, and their effects are being equated with those of meditation practices. To assess these conclusions, this paper compares psychedelic experiences in terms 1) EEG patterns, 2) brain blood-flow 3) content experience, 4) mechanism action, 5) therapeutic application. On five factors, transcendental during practice completely different: gamma vs alpha EEG...

What makes psychedelic psychotherapy work? Is it the induction of experience, with its distinct patterns hallucinations and insights, or is neural ‘shakeup’ that moves brain out regular mode functioning into a more disordered state? We consider role attention-related phenomenological changes play in transformation psychotherapy. review Letheby’s account psychotherapy, which appeals to increases...