BACKGROUND The aim of this study was to assess changes in metalloproteinases (MMP-2) and tissue inhibitor of metalloproteinases (TIMP-2) following selective laser trabeculoplasty (SLT) in patients with pseudoexfoliative glaucoma (PEXG). METHODS We enrolled 15 patients with PEXG and cataracts (PEXG-C group) and good intraocular pressure (IOP) controlled with beta-blockers and dorzolamide eye d...

A 74-year-old woman was referred to the glaucoma unit for pseudoexfoliative glaucoma. Upon presentation, visual acuity in both eyes was 20/30. Intraocular pressure was 18 mmHg in the right eye and 20 mmHg in the left eye with latanoprost eye drops. Ophthalmoscopy revealed a cup-disc ratio of 0.7 with superior neural rim notching in the right eye and concentric cup-disc ratio of 0.6 in the left ...

The aim of this work is to examine the role of circulating platelet aggregates (CPA) at pseudoexfoliation glaucoma (PXG), haemodynamic changes in the ophthalmic artery by ultrasonic color Doppler, searching for visual field progression. Vascular component at PXG and its role in VF progression dynamics has not been sufficiently explained, as well as CPA influence to ischaemic events related to o...

PURPOSE To compare ocular rigidity (OR) and outflow facility (C) coefficients in medically treated open-angle glaucoma (OAG) patients and controls, and to investigate differences in ocular pulse amplitude (OPA) and pulsatile ocular blood flow (POBF) between the two groups. METHODS Twenty-one OAG patients and 21 controls undergoing cataract surgery were enrolled. Patients with early or moderat...

PURPOSE To investigate the association of the two single-nucleotide polymorphisms (SNPs) in the lysyl oxidase-like 1 (LOXL1) gene with pseudoexfoliation syndrome (PEX), pseudoexfoliative glaucoma (PEXG), and primary open-angle glaucoma (POAG) in a Greek population-based setting, from the Thessaloniki Eye study. METHODS A total of 233 subjects with successful DNA extraction, PCR amplification,...

OBJECTIVE To compare the levels of plasma homocysteine (Hcy), vitamin B6 (vit-B6), serum vitamin B12 (vit-B12), and folate in healthy individuals and in patients with normal tension glaucoma (NTG), pseudoexfoliative glaucoma (PXG), or primary open-angle glaucoma (POAG). STUDY DESIGN A prospective controlled trial. PARTICIPANTS AND METHODS Forty healthy subjects, 48 patients with NTG, 38 pat...