OBJECTIVE Biomarkers may be helpful in screening patients with psoriasis for PsA. Our purpose was to identify serum biomarkers for psoriasis and PsA. METHODS Fifty-two patients with psoriasis (26 satisfying CASPAR classification criteria for PsA) and 26 healthy controls were recruited for our study. Patients with psoriasis and PsA were group matched for age, sex and psoriasis duration, wherea...

BACKGROUND Up to sevenfold differences were observed between total prostate-specific antigen (PSA) methods for New York State Proficiency Test samples prepared with seminal fluid PSA in human female serum. Because the PSA was mainly in its free form under these conditions, we wanted to determine whether a defined mixture of free and complexed PSA would reduce the interassay differences. METHO...

The current diagnostic modality of prostate cancer based on prostate specific antigen (PSA) and systematic biopsy is far from ideal in terms of over-diagnosing indolent prostate cancer and missing significant ones. Thus we integrated the peripheral zone volume ratio (PZ-ratio) for diagnostic refinement. This retrospective study included 247 consecutive patients who underwent initial transrectal...

OBJECTIVE We aimed to determine predictive values of extracapsular extension (ECE) in patients who had undergone radical retropubic prostatectomy (RRP) with prostate-specific antigen (PSA) values below 10 ng/mL. MATERIAL AND METHODS We retrospectively scanned data of 167 patients with PSA values below 10 ng/mL who had undergone radical retropubic prostatectomy (RRP) between April 2004 and Aug...

We studied predictors for the progression of incidental prostate cancer (PCa) to optimize the management strategies that are still controversial in the era of prostate-specific antigen (PSA). We performed advanced transurethral resection of the prostate (TURP) in 995 patients with benign prostate hyperplasia (BPH). Of these, 226 patients (22.7%) had incidental PCa. Included in the present study...

PURPOSE To investigate the relationship between rising patterns of prostate-specific antigen (PSA) before chemotherapy and PSA flare during the early phase of chemotherapy in patients with castration-resistant prostate cancer (CRPC). MATERIALS AND METHODS This study included 55 patients with CRPC who received chemotherapy and in whom pre-treatment or post-treatment PSA levels could be seriall...

BACKGROUND Prostate-specific antigen (PSA) is an important marker for the diagnosis and management of prostate cancer, and the free PSA/total PSA ratio has been shown to be efficient for distinguishing prostate cancer from benign prostatic hyperplasia. We report here the characterization of seven mouse monoclonal antibodies (mAbs) and the partial localization of two conformational epitopes iden...

Like other countries, Japan is recording a rapid increase in the incidence of prostate cancer. The use of serum PSA (prostate specific antigen) measurement as a blood marker for prostate cancer has become widespread. Higher levels of PSA are associated with a higher probability of a diagnosis of prostate cancer. Needle biopsies detect prostate cancer in 20–30% of cases with PSA levels of 4.1–10...

Prostate cancer (PC), benign prostatic hyperplasia (BPH) and prostatitis are the most common disorders of the prostate gland. Prostate specific antigen (PSA), the marker of prostate cancer has shown reasonable sensitivity but has limited specificity for distinguishing PC from BPH.This study attempts to evaluate the use of uric acid phosphate ratio as a tool in differential diagnosis of prostate...