نتایج جستجو برای: proviral load

تعداد نتایج: 150243  

2015
Luis M. Agosto Matthew Gagne Andrew J. Henderson Jessica Tyler

Chromatin influences Human Immunodeficiency Virus (HIV) integration and replication. This review highlights critical host factors that influence chromatin structure and organization and that also impact HIV integration, transcriptional regulation and latency. Furthermore, recent attempts to target chromatin associated factors to reduce the HIV proviral load are discussed.

Journal: :Journal of medical virology 2016
Fernando Medina Sebastián Quintremil Carolina Alberti Fabián Godoy María E Pando Andrés Bustamante Andrés Barriga Luis Cartier Javier Puente Yuetsu Tanaka María A Valenzuela Eugenio Ramírez

Human T-lymphotropic virus-type 1 (HTLV-1) is the etiologic agent of the neurologic disease HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Tax viral protein plays a critical role in viral pathogenesis. Previous studies suggested that extracellular Tax might involve cytokine-like extracellular effects. We evaluated Tax secretion in 18 h-ex vivo peripheral blood mononuclear ...

Journal: :The Journal of antimicrobial chemotherapy 2014
Gabriella Rozera Isabella Abbate Emanuela Giombini Antonella Castagna Andrea De Luca Francesca Ceccherini-Silberstein Alessandro Cozzi Lepri Giovanni Cassola Carlo Torti Antonella d'Arminio Monforte Giuseppe Ippolito Maria R Capobianchi

OBJECTIVES Tropism evolution of HIV-1 quasispecies was analysed by ultra-deep pyrosequencing (UDPS) in patients on first-line combination antiretroviral therapy (cART) always suppressed or experiencing virological failure episodes. METHODS Among ICONA patients, two groups of 20 patients on cART for ≥5 years, matched for baseline viraemia and therapy duration, were analysed [Group I, patients ...

2011
Emanuele Nicastri Chiara Tommasi Isabella Abbate Stefano Bonora Massimo Tempestilli Rita Bellagamba Magdalena Viscione Gabriella Rozera Anna L Gallo Jelena Ivanovic Alessandra Amendola Leopoldo Pucillo Giovanni Di Perri Maria R Capobianchi Pasquale Narciso

Background: Raltegravir is the first approved antiretroviral able to prevent HIV genome integration into the host chromosomes. The aim of the study is to test if raltegravir plasma concentrations can be associated with proviral DNA decline during raltegravir-based salvage therapy. Methods: A total of 33 multidrug-resistant HIV-infected patients were enrolled in a longitudinal open-label pilot s...

Journal: :Journal of immunology 2000
K J Jeffery A A Siddiqui M Bunce A L Lloyd A M Vine A D Witkover S Izumo K Usuku K I Welsh M Osame C R Bangham

The inflammatory disease human T cell lymphotropic virus type I (HTLV-I)-associated myelopathy (HAM/TSP) occurs in only 1-2% of HTLV-I-infected individuals and is associated with a high provirus load of HTLV-I. We hypothesize that a person's risk of developing HAM/TSP depends upon the efficiency of their immune response to the virus, which differs between individuals because of polymorphism in ...

2014
Gerónimo Gutiérrez Irene Alvarez Ramiro Merlini Flavia Rondelli Karina Trono

BACKGROUND Bovine leukemia virus (BLV) is highly endemic in many countries, including Argentina. As prevention of the spread from infected animals is of primary importance in breaking the cycle of BLV transmission, it is important to know the pathophysiology of BLV infection in young animals, as they are the main source of animal movement. In this work, we determined the proviral load and antib...

Journal: :Blood 1990
A Gessain F Saal O Gout M T Daniel G Flandrin G de The J Peries F Sigaux

Human T-cell lymphotropic virus type I (HTLV-I) proviral integration status was examined by Southern blot analysis in peripheral blood mononuclear cell (PBMC) DNA from patients presenting a tropical spastic paraparesis (TSP) and serological evidence of HTLV-I infection. Surface phenotype and morphological aspects of PBMC were also studied. A polyclonal HTLV-I proviral integration was found in t...

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