نتایج جستجو برای: proteomic
تعداد نتایج: 23982 فیلتر نتایج به سال:
The cytochrome P450 (P450) superfamily metabolizes many endogenous signaling molecules and drugs. P450 enzymes are regulated by posttranslational mechanisms in vivo, which hinders their functional characterization by conventional genomic or proteomic methods. Here we describe a chemical proteomic strategy to profile P450 activities directly in living systems. Derivatization of a mechanism-based...
The term proteomics was used for the first time in 1995 to describe large-scale protein analyses. At the same time proteomics was distinguished as a new domain of the life sciences. The major object of proteomic studies is the proteome, i.e. the set of all proteins accumulating in a given cell, tissue or organ. During the last years several new methods and techniques have been developed to incr...
MOTIVATION On the histological level the differentiation of normal epithelial tissues is well known. The phenomenon of dedifferentiation, which occurs as cells develop towards malignancy is also well described. To identify an epithelial tumor-specific proteomic profile as well as to measure the proximities between we used data from tumor tissue and adjacent normal tissue microdissected from hea...
Proteomic profiling of human disease has seen much early activity with the accessibility of the newest generation of high-throughput platforms and technologies. Nevertheless, the nature of the dynamic physiologic milieu and high dimensionality of the data has complicated major diagnostic and prognostic breakthroughs. Our recent article in Cancer Cell delineates an integrative model for culling ...
Background: Salinity is a major environmental limiting factor, which affect agricultural production. The two Manilkara seedlings (M. roxburghiana and M. zapota) with high economic importance, could not adapt well to higher soil salinity and little is known about their proteomic mechanisms. Objectives: The mechanisms responsible ...
responses of plants to salinity stress and development of salt tolerance are extremely complex and various mechanisms appear to be involved. we employed a proteomic approach to study the mechanism of plant responses to salinity in a sensitive cultivar of barley (527 line). three-week-old seedlings were treated with 300 mm nacl for 3 weeks. total proteins of fourth leaf were extracted and separa...
A multimodal proteomic analysis of the perturbations that SARS-CoV-2 and SARS-CoV induce in infected human lung epithelial cells reveals common distinct immune-evasive pathobiological mechanisms used by these coronaviruses.
Abstract BACKGROUND Invasive brain sampling is typically necessary for reliable diagnosis and prognostication of intra-axial tumors but carries risk morbidity. Liquid biopsy proximal fluids may mitigate this risk. Through direct contact with the tumor microenvironment and, as an ultra-filtrate plasma, cerebrospinal fluid be ideal matrix. Reflecting phenotype, proteomic analyses are critical. He...
Proteomics has been widely used in the last few years to look for new biomarkers and decipher the mechanism of HIV-host interaction. Herein, we review the recent developments of HIV/AIDS proteomic research, including the samples used in HIV/AIDS related research, the technologies used for proteomic study, the diagnosis biomarkers of HIV-associated disease especially HIV-associated neurocognitiv...
Data from a comparative proteomic analysis of three human breast epithelial cell lines are presented. M13SV1 cells and their tumorigenic derivatives M13SV1-R2-2 and M13SV1-R2-N1 were used. Proteomic data were obtained using 2-dimensional gel electrophoresis and subsequent identification of proteins by MALDI-TOF mass spectrometry. In a second experiment, the three cell lines were treated with di...
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