Panax notoginseng (PN) has become the most widely used dietary supplement and herbal in Asian countries. The effect of micronization on PN is not entirely clear. aim this study was to investigate effects particle size powder (PNP) potential improve bioavailability. results showed that reduction significantly changed saponins (PNS) vitro dissolution vivo pharmacokinetics. ranges from 60 214 μm. ...

Lysozyme, as a model protein, was precipitated through the formation of protein-Zn complex to micronize for subsequent encapsulation within poly (lactic-co-glycolic acid) (PLGA) microspheres. Various parameters, including pH, type and concentration of added salts and protein concentration, were modified to optimize the yield of protein complexation and precipitation. The resulting protein parti...

Oral route is the easiest and most convenient route of drug administration, being non invasive and cost effective, thereby leading worldwide drug delivery market. But major problem encountered in oral formulations (as estimated more than 50 % of oral formulations are found to be poorly aqueous soluble), is low bioavailability, giving rise to further problems like, high inter and intra subject v...

Self emulsifying is a topic of current interest for overcoming the formulation difficulties of drugs with poor aqueous solubility. SEDDS are isotropic mixture of oil, surfactant and co-surfactant with a unique ability to form fine oil-inwater (o/w) emulsions or micro emulsions upon mild agitation in the gastrointestinal tract which present the drug in a solubilized form, and the small size of f...