1. The metabolism of human antithrombin III (ATIII) was studied by using 125I-labelled tracer. 2. The plasma half-life (t0.5) was 2.71 +/- 0.26 days in normal subjects and was similar in patients with cirrhosis or primary carcinoma of liver. 3. Patients with cirrhosis had low ATIII levels, decreased intravascular mass, total body mass and decreased absolute catabolic rate, suggesting decreased ...

Severely low-protein (LP) diets induce a decrease in body weight and an increase relative food including intake (FI) rat. In the liver, changes anabolic catabolic protein pathways could transitorily participate to compensate for amino acid (AA) deficiency. The present study investigated these liver muscle metabolic on LP diet fed growing rats. Growing rats were three weeks different containing ...

The inhibitor of galactose catabolic (GAL) gene expression in Saccharomyces cerevisiae, Gal80p, interacts with the activator Gal4p and the signal transducer Gal3p and self-associates. Selection for loss of Gal80p inhibitor function yielded gal80 mutants at an extremely high rate. Out of these, 21 nonoverlapping point mutants were identified; each were due to a single-amino-acid exchange in cons...

The prognosis for haemodialysis patients is reported to be more favourable in Japan than in Europe or North America. Consequently, evaluation of the death predictors for haemodialysis patients in Japan is of considerable interest outside Japan. The Patient Registration Committee of the Japanese Society for Dialysis Therapy annually surveys the individual patient case mix, laboratory data and im...

I. Eleven obese subjects fasted for 24 d, by which time their serum albumin concentration had fallen significantly. 1251-labelled albumin was injected on day 7 of fasting to allow study of albumin metabolism. 2. Although no significant alteration occurred in either the intravascular content or the absolute catabolic rate of albumin between days 7 and 24 of fasting, the mean values for both cont...

1. Fibrinogen catabolism was studied in ten rabbits before and after suddenly elevating the intravascular pool by injecting a single dose of homologous fibrinogen equivalent to 1843% of the corresponding protein already present in this pool. Of the two metabolic tracers used, [13'I]fibrinogen was injected 3 4 days before and [1251]fibrinogen at the time of introducing the change. 2. Analysis of...

BACKGROUND & OBJECTIVES Cardiovascular disease remains the most common cause of death for patients on chronic dialysis. End stage renal disease patients undergoing dialysis imposed to reduce phosphorus intake, which likely contributes to development of vegetarian diet behaviors. Vegetarian diets are often lower in protein content, in contradiction to the recommendation that a high protein diet ...

OBJECTIVE In vitro studies showed that insulin stimulates the production of apolipoprotein AI (apoAI). Thus, we hypothesized that chronic hyperinsulinemia could contribute to the increase in the production of high-density lipoprotein apoAI that is observed in metabolic syndrome. APPROACH AND RESULTS We performed an in vivo kinetic study with stable isotope in 7 patients with insulinoma who sh...