Contractile reserve decreases with advancing age and chronic isoproterenol (ISO) administration is a well-characterized model of cardiac hypertrophy known to impair cardiovascular function. This study evaluated whether nonsenescent, mature adult rats are more susceptible to detrimental effects of chronic ISO administration than younger adult rats. Rats received daily injections of ISO (0.1 mg/k...

Isorhamnetin (ISO) is a flavonoid from plants of the Polygonaceae family and is also an immediate metabolite of quercetin in mammals. To date, the anti‑tumor effects of ISO and the underlying mechanisms have not been elucidated in lung cancer cells. The present study investigated the inhibitory effects of ISO on the growth of human lung cancer A549 cells. Treatment of the lung cancer cells with...

The effects of selective beta-adrenergic receptor agonist isoproterenol (Iso) on neuronal excitability and synaptic transmission were investigated in brain slices of rat amygdala. Iso (15 microM) produced a long-lasting enhancement of the EPSP that was not blocked by pretreatment with 20 microM D-2-amino-5-phosphonovalerate (D-APV) alone or D-APV in combination with kynuretic acid (1 mM). The s...

Research was carried out into the effect of partial and total fishmeal (FM) replacement by a vegetable animal proteins blend, as well inclusion microalgae in diets for gilthead seabream (Sparus aurata L.). Fish 64 g on initial weight were fed until apparent satiation 88 days. The control diet (FM100) contained FM main protein source, whilst FM25, FM10 FM0 diets, replaced 75%, 90% 100%, respecti...

8-Isoprostanes are bioactive lipid mediators formed via the nonenzymatic peroxidation of arachidonic acid by free radicals and reactive oxygen species. However, their cognate receptors, biological actions, and signaling pathways are poorly studied. Here, we report the effect of a variety of E- and Falpha-ring 8-isoprostanes on the release of granulocyte/macrophage colony-stimulating factor (GM-...

Background: Myocardial infarction (MI) is one of the most important causes of death worldwide. The effect of flunixin meglumine (FM) on MI is unknown. We investigated the protective effect of FM on the serum biochemical profile, malondialdehyde (MDA), and heart histology changes induced by isoproterenol (ISO) in adult male rats. Methods: Rats were randomly divided into four groups of six eac...

a study was performed to study the effect of drought stress on protein changes of five wheat genotypes. wheat genotypes were planted in early november, growing season of 2008-2009. the experiment was carried out in a factotial design with three replications. two drought stress levels (irrigated and non irrigated) and five genotype of wheat (f103-l-1-12//pony/opata, f1.158/fdl//blo/3/sh14414/cro...

Growth factors and inflammatory Ras homolog gene family member A (RhoA)/coiled-coil containing protein kinase 1 (ROCK1) pathway have been shown to regulate isoproterenol (ISO)-induced myocardial ischemia. However, the association between matrine and myocardial ischemia remains to be elucidated. The objective of this study was to explore whether matrine ameliorates ISO-induced myocardial ischemi...

Purpose: To investigate the regulatory effects of heat shock factor 1 (HSF-1) in progression postoperative cognitive dysfunction (POCD).
 Methods: Isoflurane (ISO)-induced POCD model rats was established to determine role HSF-1 POCD. Morris water maze test used evaluate learning and memory abilities while mRNA protein levels were determined by RNA extraction/quantitative real-time polymera...

Beta-Adrenoceptor agonists activate a time- and voltage-independent Cl- conductance in mammalian cardiac myocytes. To characterize the cellular signaling pathways underlying its regulation, wide-tipped pipettes fitted with a pipette perfusion device were used to record whole-cell current and to introduce nucleotides to the interior of guinea pig ventricular myocytes. Replacement of pipette GTP ...