نتایج جستجو برای: protecting group
تعداد نتایج: 1006342 فیلتر نتایج به سال:
The protection of arginine (Arg) side chains is a crucial issue in peptide chemistry because of the propensity of the basic guanidinium group to produce side reactions.pentamethyldihydrobenzofurane (Pbf), are the most widely used for this purpose. Nevertheless, Arg side chain protection remains problematic as a result of the acid stability of these two compounds. This issue is even more relevan...
The direct and chemoselective 3'-phosphoramidation, phosphorylation and acylation of nucleosides are described. Upon the discovery of a novel 3'-phosphorylamidation of therapeutic nucleoside analogues with DBU, we explored the mechanism of this rare selectivity through a combination of NMR spectroscopy and computational studies. The NMR and computational findings allowed us to develop a predict...
The protecting group tetraisopropyldisiloxane-1,3-yl has been investigated for simultaneous protection of two hydroxyls on pentopyranosides. Methyl α-D-xylopyranoside is protected in excellent regioselectivity and high yield to form the 2,3-protected xylopyranoside whereas methyl β-D-xylopyranoside gives the 3,4-protected product also with excellent regioselectivity.
Novel bichromophoric fluorescent photolabile protecting group, (5-dansyloxy-3-hydroxynaphthalen-2-yl)methyl (DNS-NQMP), allows for the independent photochemical release and fluorescent imaging of caged substrates. Irradiation of DNS-NQMP-caged alcohols and carboxylic acids with 300 or 350 nm light results in fast (k(release) ~ 10(5) s(-1)), efficient (Φ = 0.2), and quantitative release of the s...
Existing key management schemes can secure group communication efficiently, but are failed on protecting the Group Dynamic Information (GDI) that may undermine group privacy. Recently, Sun et al. proposed a scheme to hide the GDI with batch updating and phantom members inserting so that an adversary is not able to estimate the number of group members. In this paper, we first point out that thei...
24 W. Lin, D.S. Lawrence, J. Org. Chem. 2002, 67, 2723–2726. 25 H.J. Montgomery, B. Perdicakis, D. Fishlock, G.A. Lajoie, E. Jervis, J.G. Guillemette, Bioorg. Med. Chem. 2002, 10, 1919–1927. 26 M. Lu, O.D. Fedoryak, B.R. Moister, T.M. Dore, Org. Lett. 2003, 5, 2119– 2122. 27 V.G. Robu, E.S. Pfeiffer, S.L. Robia, R.C. Balijepalli, Y. Pi, T. J. Kamp, J.W. Walker, J. Biol. Chem. 2003, 278, 48154–4...
Well-defined metallic nanobowls can be prepared by extending the concept of a protecting group to colloidal synthesis. Magnetic nanoparticles are employed as "protecting groups" during the galvanic replacement of silver with gold. The replacement reaction is accompanied by spontantous dissociation of the protecting groups, leaving behind metallic nanobowls.
Protecting-group-independent cross-coupling of α-alkoxyalkyl- and α-acyloxyalkyltrifluoroborates with aryl and heteroaryl bromides is achieved through application of photoredox/nickel dual catalysis. Reactions occur under exceptionally mild conditions, with outstanding functional group compatibility and excellent observed tolerance of heteroarenes. This method offers expedient access to protect...
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