HCN J =8→ 7 sub-millimetre line emission produced in the circumstellar envelope around the extreme carbon star IRC+10216 has been imaged at sub-arcsecond angular resolution using the SMA. Supplemented by a detailed excitation analysis the average fractional abundance of HCN in the inner wind (. 5× 10 cm) is estimated to be about 4× 10, translating into a total HCN fractional abundance of 2× 10 ...

cAMP signaling in the brain mediates several higher order neural processes. Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels directly bind cAMP through their cytoplasmic cyclic nucleotide binding domain (CNBD), thus playing a unique role in brain function. Neuronal HCN channels are also regulated by tetratricopeptide repeat-containing Rab8b interacting protein (TRIP8b), an aux...

We present a search for HCN emission from four high redshift far infrared (IR) luminous galaxies. Current data and models suggest that these high z IR luminous galaxies represent a major starburst phase in the formation of spheroidal galaxies, although many of the sources also host luminous active galactic nuclei (AGN), such that a contribution to the dust heating by the AGN cannot be precluded...

The onset of spontaneous seizures in the pilocarpine model of epilepsy causes a hyperpolarized shift in the voltage-dependent activation of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel-mediated current (Ih) in CA1 hippocampal pyramidal neuron dendrites, contributing to neuronal hyperexcitability and possibly to epileptogenesis. However, the specific mechanisms by which spon...

We present here the sensitive HCN(1-0) observations made with the VLA of two submillimeter galaxies and two QSOs at high-redshift. HCN emission is the signature of dense molecular gas found in GMC cores, the actual sites of massive star formation. We have made the first detection of HCN in a submillimeter galaxy, SMM J16359+6612. The HCN emission is seen with a signal to noise ratio of 4σ and a...

Alteration in hydrocyanic acid potential (HCN-p) of the forage is one of the important objectives in sudangrass [Sorghum sudanense (Piper) Stapf] breeding programs. The effectiveness of recurrent phenotypic selection for increasing or decreasing HCN-p in sudangrass was evaluated in two cycles of individual plant selection in the cultivar 'Greenleaf. In cycle 1, HCNp means of the high and low po...

Several nonpeptide small molecules were designed as potential inhibitors of HIV protease and their structures were constructed by computer-aided molecular modeling and docked iwo the active site of HIV protease. Models of the complexes of inhibitors and the HIV protease were refined using nonbonded and H-bonding terms. The refined energy of selected complexes showed that the designed inhib...

Currently hydrogen cyanide (HCN) is industrially produced in the Czech Republic (Lucebni zavody Draslovka Kolin) and is extensively used for Czech mill fumigation. Therefore we evaluated the potential of HCN fumigant for treatment of wooden transport packages (pallets). We tested the penetration of HCN trough wooden pallet materials using gas chromatography. The preliminary results on biologica...

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are reverse voltage-dependent, and their activation depends on the hyperpolarization of the membrane and may be directly or indirectly regulated by the cyclic adenosine monophosphate (cAMP) or other signal-transduction cascades. The distribution, quantity and activation states of HCN channels differ in tissues throughout the bod...

The experiments seem to indicate that the toxicity of HCN and KCN for amebae is due to their effect on the cell membrane and not on the internal protoplasm. Concentrated solutions (N/10-N/300) of HCN or KCN produce an initial increase in viscosity of the protoplasm of amebae (immersed) which is followed by liquefaction and disintegration of the cell. Dilute solutions of HCN or KCN decrease the ...