The rise in new psychoactive substances that are available as 'research chemicals' (RCs) remains a significant forensic and legislative challenge. A number of arylcyclohexylamines have attracted attention as RCs and continue to be encountered, including 3-MeO-PCP, 3-MeO-PCE and 3-MeO-PCPr. These compounds are commonly perceived as ketamine-like dissociative substances and are believed to act pr...

Substituted 3'-thiourea derivatives of beta-thymidine (dThd) and 5'-thiourea derivatives of alpha-dThd have been evaluated for their inhibitory activity against recombinant human cytosolic dThd kinase-1 (TK-1), human mitochondrial TK-2, herpes simplex virus type 1 (HSV-1) TK, and varicella-zoster virus TK. Several substituted 3'-thiourea derivatives of beta-dThd proved highly inhibitory to and ...

The object of the work on the oxidation of optically active thio compounds to the corresponding sulfo derivatives was discussed in the preceding series of articles.’ It will be referred to in this place very briefly. It is desired, first, to follow the effect on optical rotation of the change in polarity of a single group attached to the asymmetric carbon atom; second, to observe in substituted...

In the title compound, C(12)H(14)O(4), the two acet-oxy groups are inclined by 57.92 (5)° and 62.71 (6)° to the benzene ring. An inter-molecular C-H⋯O inter-action involving the two acet-oxy groups generates a centrosymmetric dimer via an R(2) (2)(16) ring motif.

Treating 2-chloro-4-(4-chlorophenyl)-6-methylbenzo[d]-3,1-oxazinium hexachloroantimonate (1) with one equivalent of alcohol or mercaptane led, after hydrolysis with aq. NaOH, to the formation of 4,4-disubstituted-1,4-dihydro-2H-6-methyl-3,1-benzoxazin-2-ones (3). Large excess addition of alcohol afforded either 4’-chloro-2-isocyanato-5-methylbenzophenone disubstitutedketal (4) or N-{2[(4-chloro...

The potency of hallucinogenic amphetamine derivatives of the 1-(2,5-dimethoxy-4-alkylphenyl)-2-aminopropane type drops dramatically when the length of the 4-alkyl substituent exceeds propyl or when the substituent is branched. This investigation was directed toward evaluating changes in behavioral and biochemical pharmacology resulting from introducing chirality into the 4-alkyl group of such a...

A model for computing image ow in image sequences containing a very wide range of instantaneous ows is proposed. This model integrates the spatio-temporal image derivatives from multiple temporal scales to provide both reliable and accurate instantaneous ow estimates. The integration employs robust regression and automatic scale weighting in a generalized brightness constancy framework. In addi...

Neophylpalladium complexes of the type [Pd(CH(2)CMe(2)Ph)(N-O)(L)], where N-O is picolinate or a related bidentate, monoanionic ligand (6-methylpyridine-2-carboxylate, quinoline-2-carboxylate, 2-pyridylacetate or pyridine-2-sulfonate) and L is pyridine or a pyridine derivative, efficiently catalyze the oxidation of a range of aliphatic, benzylic and allylic alcohols with oxygen, without requiri...