BACKGROUND/AIMS Endoscopic submucosal dissection (ESD) is accepted as a treatment for gastric neoplasms and usually requires deep sedation. The aim of this study was to evaluate the safety and efficacy profiles of deep sedation induced by continuous propofol infusion with or without midazolam during ESD. METHODS A total of 135 patients scheduled for ESDs between December 2008 and June 2010 we...

STUDY OBJECTIVE To evaluate the effect of propofol infusion for both induction and maintenance of anesthesia on hemodynamics and recovery in elderly patients compared with conventional thiopental-isoflurane anesthesia. DESIGN Randomized, prospective, study. SETTING Teaching hospital. PATIENTS 60 nonpremedicated ASA physical status I, II, and III adult elderly patients scheduled to undergo...

UNLABELLED The administration of esmolol decreases the propofol blood concentration, preventing movement after skin incision during propofol/morphine/nitrous oxide anesthesia. However, interaction with esmolol has not been tested when propofol is infused alone. Accordingly, we tested the hypothesis that esmolol decreases the propofol blood concentration, preventing response to command (CP50-awa...

PURPOSE To determine the effects of propofol on the cardiac conduction system in dogs with pharmacological autonomic blockade. METHODS In eight mongrel dogs receiving 6 mg.kg-1.hr-1 propofol and vecuronium under pharmacological autonomic blockade with atropine and propranolol the infusion rates of propofol were increased from 6, (baseline), to 12, 18 and 24 mg.kg-1.hr-1 at 60-min intervals. A...

We have studied the effects of conscious sedation with propofol on long latency components of the auditory event-related potential (ERP) in 10 normal volunteers (aged 21-41 yr) receiving propofol 75 micrograms kg-1 min-1 i.v. We examined the effects of propofol on ERP amplitudes and latencies, and their relationship to delayed recognition performance using a verbal memory test, a selective atte...

OBJECTIVE Pulmonary complications are important sepsis (such as ARDS, diffuse pneumonia). Acute respiratory distress syndrome (ARDS) is characterized by the extensive migration of neutrophils into alveoli of the lungs. Propofol and midazolam are the most widely used agents for sedation in intensive care units. Aimed to investigate the effects of anaesthesia with propofol and midazolam on measur...