We have carried out a series of extended unbiased molecular dynamics (MD) simulations (up to 10 μs long, ∼162 μs in total) complemented by replica-exchange with the collective variable tempering (RECT) approach for several human telomeric DNA G-quadruplex (GQ) topologies with TTA propeller loops. We used different AMBER DNA force-field variants and also processed simulations by Markov State Mod...

A blade element momentum theory propeller model is coupled with a commercial RANS solver. This allows the fully appended self propulsion of the autonomous underwater vehicle Autosub 3 to be considered. The quasi-steady propeller model has been developed to allow for circumferential and radial variations in axial and tangential inflow. The non-uniform inflow is due to control surface deflections...

BACKGROUND AND AIMS Perforator flaps increasingly find acceptance and use in hand reconstructive surgery. A propeller flap is an island flap that moves from one orientation to another by rotating around its vascular pedicle. It is now possible to design propeller flaps based on a single perforator, so-called "perforator-based propeller flaps," but they are more prone to vascular impairment when...

Between October, 2003, and August, 2009, 13 patients were admitted to our hospital for management of propeller related injuries. These injuries ranged in severity from superficial lacerations that did not require closure to severe, devastating injuries with limb loss (Table 1). No patients died of propeller injuries after reaching the hospital during the period of this study. Five of the injuri...

Proteases have a variety of strategies for selecting substrates in order to prevent uncontrolled protein degradation. A recent crystal structure determination of prolyl oligopeptidase has suggested a way for substrate selection involving an unclosed seven-bladed beta-propeller domain. We have engineered a disulfide bond between the first and seventh blades of the propeller, which resulted in th...

A practical online optimization scheme is developed for performance optimization of an electrical aircraft propulsion system. The goal is to minimize the power extraction of the propulsion system for any given thrust value. The online optimizer computes the optimum pitch angle of a variable pitch propeller by minimizing the power of the system for a command thrust value. This algorithm is teste...

BPM research has been of great importance in Germany since the early 1990s. In Russia, increased competition and new IT possibilities have only recently forced both companies and governmental institutions to start taking benefits from BPM. Against this background, the workshop PropelleR 2012 brought together German and Russian BPM researchers as well as practitioners in order to discuss recent ...

Purpose Q-ball imaging [1] has been proven to have ability of resolving intra-voxel fiber crossings. Compared to DSI (Diffusion Spectrum Imaging) [2] it only requires one-half diffusion-weighted images (515-dirs vs 252-dirs), and takes only about 30 minutes to acquire whole brain data. However 30 minutes acquisition time still hinders its clinical applications. Therefore, we propose PROPELLER Q...

Channel wing is a propeller-coupling layout that has good low-speed performance and S/VTOL potential. Focused on the application of this at stage, paper attempts to find interaction mechanism for distributed propeller channel wing. Firstly, computation method based RANS equations propeller–wing integration was established with Momentum Source Method, which compared unsteady Sliding Mesh validat...

An inviscid actuator disk model is embedded in a three-dimensional low-order panel method code for inviscid incompressible flow in order to study the propeller effects on an arbitrary body. The actuator disk model predicts the time–averaged induced velocities in the slipstream of a propeller with an arbitrary radial distribution of load. The model is constructed by superposition of four vortici...