نتایج جستجو برای: prop1 gene
تعداد نتایج: 1141423 فیلتر نتایج به سال:
Abstract Hypopituitarism with deficiency of one or more pituitary hormones (combined hormone CPHD) can vary in severity and age at presentation. Additionally, the abnormalities may evolve time necessitating frequent evaluation. These hormonal deficits also be present as part a syndrome, patients showing extrapituitary such eye forebrain malformations. Over past decade, there has been an explosi...
Long-living Ames dwarf (df/df) mice are homozygous for a mutation of the Prop1(df) gene. As a result, mice are deficient in growth hormone (GH), prolactin (PRL) and thyrotropin (TSH). In spite of the hormonal deficiencies, df/df mice live significantly longer and healthier lives compared to their wild type siblings. We studied the effects of calorie restriction (CR) on the expression of insulin...
Wnt signaling is important in organogenesis, and aberrant signaling in mature cells is associated with tumorigenesis. Several members of the Wnt family of signaling molecules are expressed in the developing pituitary gland. Wnt5a is expressed in the neuroectoderm that induces pituitary gland development and has been proposed to influence pituitary cell specification. We discovered that mice def...
Puberty is a complex physiological event by which animals mature into an adult capable of sexual reproduction. In order to enhance our understanding of the genes and regulatory pathways and networks involved in puberty, we characterized the transcriptome of five reproductive tissues (i.e. hypothalamus, pituitary gland, ovary, uterus, and endometrium) as well as tissues known to be relevant to g...
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