Model-free deep reinforcement learning (RL) methods have been successful in a wide variety of simulated domains. However, a major obstacle facing deep RL in the real world is the high sample complexity of such methods. Unbiased batch policy-gradient methods offer stable learning, but at the cost of high variance, which often requires large batches, while TD-style methods, such as off-policy act...

ABSTRACT Three 2'-aminochalcone derivatives (E)-1-(2-aminophenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one, (E)-1-(2-aminophenyl)-3-(3,4-dihydroxyphenyl)prop-2-en-1-one, and (E)-1-(2-amino-4,5-dimethoxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one, have been synthesized, characterized, and tested in vitro in order to assess their antioxidant activity. All compounds were characterized on the basis of 1H ...

BACKGROUND Accurate determination of pulmonary vascular resistance (PVR) is an important component in the evaluation and treatment of pediatric patients with pulmonary hypertension. We developed a novel technique, based on the concept of flow propagation, to estimate PVR noninvasively. The hypothesis is that changes in PVR cause changes in the velocity propagation (Vel(prop)) within the main pu...

Experimental studies are presented in this paper on the stability of structural steel props. Three full-scale prop specimens with various geometric properties were constructed and tested statically and elastically in the lab, in order to obtain the elastic strength of the props. The total unsupported length is 6 m for the three props. The outer and inner diameters are 150 mm and 140 mm, 138 mm ...

Adrenergic responses are crucial for hypoglycemic recovery. Epinephrine increases glucose production, lipolysis, and peripheral insulin resistance as well as blood flow and glucose delivery. Sympathetic activation causes vasoconstriction and reduces glucose delivery. To determine the effects of alpha- and beta-adrenergic activity on muscle glucose uptake during hypoglycemia, we studied forearm ...

Vegetable consumption by young children does not meet national recommendations in either the United States or in Europe due in part to the bitter taste of vegetables. Cruciferous vegetables contain natural bitter-tasting substances that share the same chemical structure as phenylthiocarbamide (PTC) and its chemical derivative 6-n-propylthiouracil (PROP). The degree to which the bitter taste fro...

BACKGROUND The effects of anesthetics on ischemia-induced ventricular arrhythmias remain poorly studied. This study investigated the effects of propofol and sevoflurane on the survival rate and morbidity as a result of ventricular arrhythmias, and defined a possible mechanism for the arrhythmogenic properties of anesthetics during acute myocardial ischemia. METHODS Under anesthesia with intra...

We extend Lawvere-Pitts prop-categories (aka. hyperdoctrines) to develop a general framework for providing “algebraic” semantics nonclassical first-order logics. This includes natural notion of substitution, which allows logics be considered as structural closure operators just propositional are in abstract algebraic logic. then establish an extension the homomorphism theorem from universal alg...

Abstract We introduce the concept of TRAP (Traces and Permutations), which can roughly be viewed as a wheeled PROP (Products Permutations) without unit. TRAPs are equipped with horizontal concatenation partial trace maps. Continuous morphisms on an infinite-dimensional topological space smooth kernels (respectively, smoothing operators) closed manifold form but not PROP. build free objects in c...

The title thia-calix[4]arene derivative, C(36)H(34)Br(2)O(8)S(4), adopts an unusual pinched cone conformation with the prop-oxy-substituted benzene rings inclined inward [forming a dihedral angle of 33.4 (1)°] and with the brominated benzene rings bent outward, making a dihedral angle of 66.1 (1)°. In the crystal, the mol-ecules form chains along [001] via C-H⋯S hydrogen bonds and S⋯S contacts ...