نتایج جستجو برای: promastigote

تعداد نتایج: 940  

Journal: :Annual Research & Review in Biology 2017

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Journal: :International Journal of Current Research and Academic Review 2016

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Journal: :Genes 2020

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Journal: :Infection and Immunity 1985

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2006
Haytham A. Zakai HAYTHAM A. ZAKAI SAMEER K. ZIMMO

The antiporliferative effect induced in vitro by two antifungal compounds, the azole itraconazole and the allylamine terbinafine on Leishmania major promastigotes are reported. Treatment of promastigote cultures with itraconazole or with terbinafine induced growth arrest. Concentrations of 0.75 μ/l or more of itraconazole induced cell lysis after 72 hours. However, even relatively large concent...

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Journal: :Organic & biomolecular chemistry 2015
Aline Alves dos Santos Naujorks Adriano Olímpio da Silva Rosangela da Silva Lopes Sérgio de Albuquerque Adilson Beatriz Maria Rita Marques Dênis Pires de Lima

Herein, we report the synthesis of 12 new naphthoquinone derivatives, 6 substituted 1,4-naphthoquinones and 6 heterocycle-fused naphthoquinones, as well as evaluation of their trypanocidal and leishmanicidal activities. Compounds 11a and 13a were active against the amastigote stage of T. cruzi and showed low cytotoxic effects. With respect to leishmanicidal assays, all compounds were inactive a...

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Journal: :Antimicrobial agents and chemotherapy 2015
Sofia Cortes Andreia Albuquerque Lília I L Cabral Liliana Lopes Lenea Campino Maria L S Cristiano

Leishmaniasis is among the world's most neglected diseases. Currently available drugs for treatment present drawbacks, urging the need for more effective, safer, and cheaper drugs. A small library of artemisinin-derived trioxanes and synthetic trioxolanes was tested against promastigote and intramacrophage amastigote forms of Leishmania infantum. The trioxolanes LC50 and LC95 presented the best...

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Journal: :Revista do Instituto de Medicina Tropical de Sao Paulo 2010
Marley García Parra Lianet Monzote Fidalgo Judith Mendiola Martinez Ana Margarita Montalvo Alvarez Olga Valdés Iglesias

In this study, a methanolic extract from Echinaster (Othilia) echinophorus was evaluated for activity against Leishmania amazonensis. The extract showed activity against the promastigote and amastigote forms with IC50 values of 62.9 and 37.5 microg.mL-1 respectively. This extract showed a moderate toxicity on macrophages from BALB/c mice. A dose of 100 mg/kg/day was effective when administered ...

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ژورنال: مجله علوم پزشکی رازی 2009
اخلاقی, لامع, بنده‌پور, مژگان, شاددل, مینو, اورمزدی, هرمزد, کاظمی, بهرام,

    Background and Aim: Leishmania major p4 gene is normally expressed during amastigote form of the parasite and can be a good candidate for producing an effective vaccine. The aim of this study is to clone p4 gene in a suitable vector for further vaccine production studies .Materials and Methods: This is an experimental study. Leishmania promastigote was grown in N.N.N. medium and later in th...

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Journal: :Proceedings of the National Academy of Sciences of the United States of America 2006
Ger van Zandbergen Annalena Bollinger Alexander Wenzel Shaden Kamhawi Reinhard Voll Matthias Klinger Antje Müller Christoph Hölscher Martin Herrmann David Sacks Werner Solbach Tamás Laskay

The obligate intracellular pathogen Leishmania major survives and multiplies in professional phagocytes. The evasion strategy to circumvent killing by host phagocytes and establish a productive infection is poorly understood. Here we report that the virulent inoculum of Leishmania promastigotes contains a high ratio of annexin A5-binding apoptotic parasites. This subpopulation of parasites is c...

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  • " +i+ "
    • "; pgn_html+=pgn_li; } document.getElementById("pgn-ul").innerHTML=pgn_html var pgn_links = document.querySelectorAll('.mypgn'); pgn_links.forEach(function(pgn_link) { pgn_link.addEventListener('click', paginate) }) } function post_and_fetch(data,url) { showLoading() xhr = new XMLHttpRequest(); xhr.open('POST', url, true); xhr.setRequestHeader('Content-Type', 'application/json; charset=UTF-8'); xhr.onreadystatechange = function() { if (xhr.readyState === 4 && xhr.status === 200) { var resp = xhr.responseText; resp_json=JSON.parse(resp) resp_place = document.getElementById("search_result_div") resp_place.innerHTML = resp_json['results'] search_meta = resp_json['meta'] update_search_meta(search_meta) update_pagination() hideLoading() } }; xhr.send(JSON.stringify(data)); } function unfilter() { url=/search_year_filter/ var term=document.getElementById("search_meta_data").dataset.term var data={ "year":"unfilter", "term":term, "pgn":1 } filtered_res=post_and_fetch(data,url) } function deactivate_all_bars(){ var yrchart = document.querySelectorAll('.ct-bar'); yrchart.forEach(function(bar) { bar.dataset.active = false bar.style = "stroke:#71a3c5;" }) } year_chart.on("created", function() { var yrchart = document.querySelectorAll('.ct-bar'); yrchart.forEach(function(check) { check.addEventListener('click', checkIndex); }) }); function checkIndex(event) { var yrchart = document.querySelectorAll('.ct-bar'); var year_bar = event.target if (year_bar.dataset.active == "true") { unfilter_res = unfilter() year_bar.dataset.active = false year_bar.style = "stroke:#1d2b3699;" } else { deactivate_all_bars() year_bar.dataset.active = true year_bar.style = "stroke:#e56f6f;" filter_year = chart_data['labels'][Array.from(yrchart).indexOf(year_bar)] url=/search_year_filter/ var term=document.getElementById("search_meta_data").dataset.term var data={ "year":filter_year, "term":term, "pgn":1 } filtered_res=post_and_fetch(data,url) } } function showLoading() { document.getElementById("loading").style.display = "block"; setTimeout(hideLoading, 10000); // 10 seconds } function hideLoading() { document.getElementById("loading").style.display = "none"; } -->