CONTEXT Use of prolotherapy (injection of growth factors or growth factor stimulators). OBJECTIVE Determine the effects of dextrose prolotherapy on knee osteoarthritis with or without anterior cruciate ligament (ACL) laxity. DESIGN Prospective randomized double-blind placebo-controlled trial. SETTING Outpatient physical medicine clinic. PATIENTS OR OTHER PARTICIPANTS Six months or more ...

CONTEXT Use of dextrose prolotherapy. Prolotherapy is defined as injection that causes growth of normal cells or tissue. OBJECTIVE Determine the 1 and 3 year efficacy of dextrose injection prolotherapy on anterior cruciate ligament (ACL) laxity. After year 1, determine patient tolerance of a stronger dextrose concentration (25% versus 10%). DESIGN Prospective consecutive patient trial. SE...

Background: Osteoarthritis currently remains a significant health problem due to its high prevalence and morbidity rate. Radiological examination is still used as gold standard determine the severity of knee osteoarthritis by using Kellgren-Lawrence grading. Dextrose prolotherapy has been known be effective in treating pain osteoarthritis, but none compared efficacy between mild moderate-severe...

As sports related injuries such as Achilles tendinopathy are prevalent, it is important to investigate new treatment modalities which safe, easy apply and effective. Over the last decade, glucose 5% injections have received more attention among clinicians. Unfortunately, no large randomized clinical trials confirmed their effectiveness so far. This article invites medical community for further ...