نتایج جستجو برای: progesterone receptor gene

تعداد نتایج: 1591587  

Journal: :iranian journal of pathology 2015
sepideh siadati majid sharbatdaran novin nikbakhsh naser ghaemian

background and objectives: breast cancer is the most common malignancy among women in the world. the aim of this study was to assess estrogen receptor (er), progesterone receptor (pr) and her-2/neu of infiltrating ductal carcinoma (idc) with tumor size, histologic grade, lymph node metastasis and age. methods: this study was carried out on 300 tissue blocks ofpatients with idc who underwent mas...

Journal: :Hormones and behavior 1997
S K Mani J D Blaustein B W O'Malley

Hormonal induction of sexual receptivity in ovariectomized female mice can be effectively reinstated by sequential administration of estradiol and progesterone. In this regard, mice appear to be similar to other rodents. While it is generally accepted that hypothalamic progesterone receptors function as estradiol-induced transcription factors in the induction of sexual receptivity in rats, hams...

Journal: :Molecular endocrinology 2001
Z M Lei S Mishra W Zou B Xu M Foltz X Li C V Rao

LH/hCG receptors were disrupted by gene targeting in embryonic stem cells. The disruption resulted in infertility in both sexes. The gonads contained no receptor mRNA or receptor protein. Serum LH levels were greatly elevated, and FSH levels were moderately elevated in both sexes; estradiol and progesterone levels decreased but were not totally suppressed in females; testosterone levels were dr...

Journal: :iranian journal of public health 0
a hossein-nezhad national institute of genetic engineering and bio technology, tehran, iran gh ahangari national institute of genetic engineering and bio technology, tehran, iran b larijani endocrinology and metabolism research center, tehran university of medical sciences, iran

background: to evaluate vdr gene variation and its interaction with immune regulatory molecules in osteoporosis. methods: totally 205 pre and postmenopausal women were recruited in the study. after an overnight fast, peripheral blood was taken and centrifuged to sprat serum for measurement of serum parathyroid hormone, 25 hydroxyvitamin d, osteocal­cin and cross laps. the fok i polymorphism in ...

Journal: :The Journal of Steroid Biochemistry and Molecular Biology 2009

2012
Alok Pant Irene I. Lee Zhenxiao Lu Bo R. Rueda Julian Schink J. Julie Kim

Progestin resistance is a major obstacle to treating early stage, well-differentiated endometrial cancer as well as recurrent endometrial cancer. The mechanism behind the suboptimal response to progestin is not well understood. The PTEN tumor suppressor gene is frequently mutated in type I endometrial cancers and this mutation results in hyperactivation of the PI3K/AKT pathway. We hypothesized ...

Journal: :Cancer research 2005
Hironori Ishibashi Takashi Suzuki Satoshi Suzuki Hiromichi Niikawa Liangying Lu Yasuhiro Miki Takuya Moriya Shin-Ichi Hayashi Masashi Handa Takashi Kondo Hironobu Sasano

A possible involvement of gender-dependent factors has been postulated in development of human non-small-cell lung cancers (NSCLC), but its details remain unclear. In this study, we examined biological significance of progesterone receptor in NSCLCs. Progesterone receptor immunoreactivity was detected in 106 of 228 NSCLCs (46.5%). Progesterone receptor-positive NSCLC was frequently detected in ...

Majid Pouya, Maryam Zakerihamidi, Nafiseh Koochaki, Shahrbanoo Keihanian,

Background: Breast cancer is the most commonly diagnosed and the leading cause of cancer death among females worldwide. The rate of breast cancer incidence among Iranian women is 17% of all cancers, it has been ranked first in Iran. This study aimed to investigate the factors affecting axillary lymph node involvement in female patients with breast cancer. Methods: A cross-sectional study was c...

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