objective: the appropriate interaction between a blastocyst and the endometrium is essential for successful implantation. numerous factors, including hormone receptors (progesterone receptor), cytokines [leukemia inhibitory factors (lif)], and adherence molecules such as e-cadherin are involved in the cross-talk that occurs between the embryo and endometrium. studies show that a lack of these g...

background and objective: male breast carcinoma (mbc) is an unusual form of neoplasia, representing 0.7 to 1 percent of all breast cancer cases. usually, the carcinoma affects patients after the sixth decade. the aim of this study was to evaluate the status of estrogen and progesterone receptors (er and pr) and prognostic factors (p53 and her-2/neu) in a series of male patients with breast canc...

A battery of sex steroids were used to check their effect on mouse melanoma (B16F10) cell growth in-vitro. Progesterone and its synthetic receptor antagonist RU-486 showed maximum inhibition on in-vitro melanoma cell growth [1]. Further research work showed that the inhibition by progesterone was not a toxic, spurious or non-specific effect on mouse melanoma cell growth and the inhibition by pr...

The effects of progesterone on breast epithelial cells remain poorly defined with observations showing both proliferative and antiproliferative effects. As an example, progesterone levels correlate with increased epithelial cell proliferation, but there is discordance between the dividing cells and the cells with nuclear progesterone receptor expression. The release of paracrine growth factors ...

The effects of cadmium on estrogen receptor and other estrogen-regulated genes in the human breast cancer cell line MCF-7 were studied. Treatment of MCF-7 cells with 1 microM cadmium decreased the level of estrogen receptor 58%. Cadmium induced a parallel decrease in estrogen receptor mRNA (62%). Progesterone receptor levels increased 3.2-fold after cadmium treatment. This induction was blocked...

What is EllaOne? EllaOne contains 30 mg ulipristal acetate (UPA), a synthetic selective progesterone receptor modulator, which has antagonistic and partial agonistic effects at the progesterone receptor level. Consequently, UPA should prevent the gene transcription normally activated by progesterone to produce the necessary proteins to support pregnancy. Over the last 10 years, other progestero...

The aim of this study was to investigate whether night work is related to breast cancer receptor status. The effect of night work on the risk of estrogen receptor– and progesterone receptor–defined breast cancers was evaluated in 513 nurses diagnosed with breast cancer between 1996 and 2007 and in 757 frequency-matched controls, all of whom were selected from a cohort of Norwegian nurses. Odds ...

Antiprogestins inhibit progesterone action by competing for binding to the progesterone receptor and are potentially important pharmaceuticals in fertility control and cancer therapy. Why the complex of antiprogestins and progesterone receptor is functionally inactive is unclear. Present models are based on indirect evidence, such as transfection competition assays and in vitro DNA binding stud...

The aim of this study was to investigate whether night work is related to breast cancer receptor status. The effect of night work on the risk of estrogen receptor- and progesterone receptor-defined breast cancers was evaluated in 513 nurses diagnosed with breast cancer between 1996 and 2007 and in 757 frequency-matched controls, all of whom were selected from a cohort of Norwegian nurses. Odds ...