Many of the newer antiarrhythmic agents are said to cause minimal myocardial depression, but their hemodynamic effects have not been invasively evaluated and compared in patients with severe chronic heart failure. In a randomized, crossover study, the hemodynamic responses to single oral doses of procainamide (750 mg), tocainide (600 mg), and encainide (50 mg) given to 21 patients with severe c...

We describe a modified colorimetric method for determining procainamide in plasma by use of a diazotization and coupling reaction with N-(1-naphthyl)-ethylenediamine dihydrochloride (Marshall's reagent). The sensitivity of the assay is increased twofold over the originally reported colorimetric method, and the lower limit of detection for the assay of a 1.0-ml plasma sample has been decreased t...

We describe a simple, rapid fluorometric assay for separate quantitative analysis of procainamide and N-acetylprocainamide in mixtures. The effective lenear range (fluorescence vs. concentration) in serum is 0.1 to 10.0 mg/liter, regardless of the ratio (by weight) of the two drugs from 1:10 to 10:1. Analytical recoveries by the extraction method used were 100.0 +/- 3.0% and 98.0 +/- 4.0%, resp...

Previous workers have shown that under certain clinical and experimental conditions, quinidine potentiates the neuromuscular blocking action of suxamethonium. This effect of quinidine has been demonstrated experimentally in a nerve-musde preparation in vivo while another antifibrillatory drug, procainamide, has also been shown to potentiate suxamethonium. Possible explanations of these drug int...

delayed repolarization syndromes. Mod Concepts Cardiovasc Dis 45: 117, 1976 28. Castellanos A, Salhanick L: Electrocardiographic patterns of procainamide cardiotoxicity. Am J Med Sci 253: 52, 1967 29. Epstein MA: Ventricular standstill during the intravenous procainamide treatment of ventricular tachycardia. Am Heart J 45: 890, 1953 30. Seiklos P, Chalme TM, Evans DW: Ventricular tachycardia af...

This paper gives a new integrable hierarchy of nonlinear evolution equations. In this hierarchy there are the following representative equations: ut = ∂ 5 xu − 2 3 , ut = ∂ 5 x (u 1 3 )xx − 2(u 1 6 )x u ; uxxt + 3uxxux + uxxxu = 0. The first two are in the positive order hierarchy while the 3rd one is in the negative order hierarchy. The whole hierarchy is shown integrable through solving a key...

The effects of antiarrhythmic drugs on electrograms have implications for arrhythmiadetection algorithms in implantable antitachycardia devices. Filtered and unfiltered intra-atrial electrograms were analyzed in eight patients who received procainamide (50 mg/min iv, up to 1000 mg) during 11 episodes of atrial fibrillation. Continuous recordings were made before, during, and after the infusion....

The effects of antiarrhythmic drugs on electrograms have implications for arrhythmiadetection algorithms in implantable antitachycardia devices. Filtered and unfiltered intra-atrial electrograms were analyzed in eight patients who received procainamide (50 mg/min iv, up to 1000 mg) during 11 episodes of atrial fibrillation. Continuous recordings were made before, during, and after the infusion....