نتایج جستجو برای: proapoptotic gene

تعداد نتایج: 1144687  

Journal: :Erzincan University Journal of Science and Technology 2023

A good understanding of the pathogenesis breast cancer, in which 2020 an estimated 684,996 women across world died, plays a vital role development treatment methods. In recent years, estrogen receptor (ER), progesterone (PR), and Epidermal Growth Factor receptor-2 (HER2) expression levels have been substantial prognostic markers. The combinational therapy approach is use two or more active ingr...

2017
Laura Giusti Morena Gabriele Giuseppe Penno Monia Garofolo Vincenzo Longo Stefano Del Prato Daniela Lucchesi Laura Pucci

Endogenous and exogenous signals derived by the gut microbiota such as lipopolysaccharides (LPS) orchestrate inflammatory responses contributing to development of the endothelial dysfunction associated with atherosclerosis in obesity, metabolic syndrome, and diabetes. Endothelial progenitor cells (EPCs), bone marrow derived stem cells, promote recovery of damaged endothelium playing a pivotal r...

Journal: :Molecular pharmacology 2001
S J Baek K S Kim J B Nixon L C Wilson T E Eling

The antitumorigenic activity of nonsteroidal anti-inflammatory drugs (NSAIDs), cyclooxygenase (COX) inhibitors, is well established, but responsible molecular mechanisms are not fully understood. NSAIDs stimulate apoptosis by COX dependent and independent mechanisms in colorectal cells in culture. Identification of genes regulated by COX inhibitors could lead to a better understanding of their ...

Journal: :Cancer research 2000
S Kagawa J Gu S G Swisher L Ji J A Roth D Lai L C Stephens B Fang

Antitumor effects of the proapoptotic Bax gene have been evaluated in vitro and in vivo by a binary adenovirus system expressing the human Bax gene. Overexpression of the Bax gene in cultured cell lines from human lung carcinoma results in caspase activation, apoptosis induction, and cell growth suppression. Intratumoral injection of adenovirus vector expressing the Bar gene suppressed growth o...

Journal: :Cancer research 2014
Antonina Giammanco Valerie Blanc Grace Montenegro Coen Klos Yan Xie Susan Kennedy Jianyang Luo Sung-Hee Chang Timothy Hla Ilke Nalbantoglu Sekhar Dharmarajan Nicholas O Davidson

HuR is a ubiquitous nucleocytoplasmic RNA-binding protein that exerts pleiotropic effects on cell growth and tumorigenesis. In this study, we explored the impact of conditional, tissue-specific genetic deletion of HuR on intestinal growth and tumorigenesis in mice. Mice lacking intestinal expression of HuR (Hur (IKO) mice) displayed reduced levels of cell proliferation in the small intestine an...

Journal: :The Journal of clinical investigation 2007
Chee-Onn Leong Nick Vidnovic Maurice Phillip DeYoung Dennis Sgroi Leif W Ellisen

Breast cancers lacking estrogen and progesterone receptor expression and Her2 amplification exhibit distinct gene expression profiles and clinical features, and they comprise the majority of BRCA1-associated tumors. Here we demonstrated that the p53 family member p63 controls a pathway for p73-dependent cisplatin sensitivity specific to these "triple-negative" tumors. In vivo, DeltaNp63 and TAp...

Journal: :Collegium antropologicum 2007
Larisa Prpić Massari Marija Kastelan Franjo Gruber

Basal cell carcinoma and squamous cell carcinoma, collectively termed non-melanoma skin cancers are the most common malignant tumors in humans. Basal cell carcinoma grows slowly and metastatic spread is very rare. Squamous cell carcinoma is characterized by infiltrative, destructive growth and metastasis. Long-term exposure of skin to UV light has a great impact on development of these epiderma...

2012
Giovanni Ferrari Vitaly Terushkin Martin J. Wolff Xiaodong Zhang Cristina Valacca Paolo Poggio Paolo Mignatti

TGF-b1 and VEGF, both angiogenesis inducers, have opposing effects on vascular endothelial cells. TGF-b1 induces apoptosis; VEGF induces survival. We have previously shown that TGF-b1 induces endothelial cell expression of VEGF, which mediates TGF-b1 induction of apoptosis through activation of p38mitogen-activated protein kinase (MAPK). Because VEGF activates p38 but protects the cells from ap...

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