HER2-positive breast cancer occurs in 15–20% of patients and is associated primarily with a poor prognosis the disease need for highly specific targeted therapy. Despite clinical importance determining HER2/neu, traditional diagnostic methods have their disadvantages require study new additional research techniques. The information presented this review makes it possible to consider current tre...

This paper is devoted to the study of establishing sufficient conditions for existence and uniqueness of positive solution to a class of non-linear problems of fractional differential equations. The boundary conditions involved Riemann-Liouville fractional order derivative and integral. Further, the non-linear function $f$ contain fractional order derivative which produce extra complexity. Than...

pro-market economists usually present “competition” as the only solution of government’s inefficiencies. therefore, having given too much credence to the private sector in economy, they choose market strategy rather than state strategy in economic policies, prizing market choice above state choice, thereby advising strongly privatization policies in the economic system in order to inject ration...

The topological analysis of chaos based on a knot-theoretic characterization of unstable periodic orbits has proven to be a powerful method, however knot theory can only be applied to three-dimensional systems. Still, the core principles upon which this approach is built--determinism and continuity--apply in any dimension. We propose an alternative framework in which these principles are enforc...

This paper explores the concept of adaptive research design, in which topic, theoretical framing, method, and data are principle open to adaptation during process. The main premise is that adaptations one element process can trigger changes other elements. Both positive negative reasons for adaptivity discussed along with various valid limiting particular cases. Grasping different couplings bet...

Past work has demonstrated that people’s moral judgments can influence their judgments in a number of domains that might seem to involve straightforward matters of fact, including judgments about freedom, causation, the doing/allowing distinction, and intentional action. The present studies explore whether the effect of morality in these four domains can be explained by changes in the relevance...