Journal of Orthopaedic Research 23 (2005) 142-149 Journal of Orthopaedic Research www.elsevier.com/locate/orthres Spatial organization of types I and II collagen in the canine meniscus Helen E. Kambic, Cahir A. McDevitt* Department of Biomedical Engineering and Orthopaedic Research Center, Lerner Research Institute, The Cleveland Clinic Foundation, ND-20, 9500 Euclid Avenue, Cleveland, OH 44195...

Genomic alterations of the 18q chromosomal region have been observed in prostate cancer.We performed array comparative genomic hybridization experiments using prostate cancerspecimens and identified the gain of copy number of a small region at 18q22.1. This relativelygene-poor region includes two cellular adhesion genes, the type II cadherins cadherin 7 andcadherin 19. Alter...

Decreased mitochondrial oxidative phosphorylation (OXPHOS) is one of the hallmarks of cancer. To date the identity of nuclear gene(s) responsible for decreased OXPHOS in tumors remains unknown. It is also unclear whether mutations in nuclear gene(s) responsible for decreased OXPHOS affect tumorigenesis. Polymerase γ (POLG) is the only DNA polymerase known to function in human mitochondria. Muta...

Lipocalin 2 (LCN2, also known as NGAL) is a secreted glycoprotein and its elevated expression has been observed in breast cancers. However, the importance of LCN2 in breast tumorigenesis is unclear. Here, we employed a spontaneous mammary tumor mouse model showing that MMTV-ErbB2(V664E) mice lacking of mLCN2 had significantly delayed mammary tumor formation and metastasis with reduced MMP-9 act...

The Guthion-resistant strain of walnut aphid parasite, Trio x y s p a II i d us. was mass reared in the greenhouse on potted walnut trees and released into five commercial walnut blocks near Colusa, Stockton, Modesto, and Hanford. Parasites successfully established in four of the five sites, surviving on field rates of Guthion and Supracide. The Guthion-resistant strain persisted in the release...

revision date: May 2008 This abstract was prepared by the principal investigator for the project. Please see www.americanchemistry.com/lri for more information about the LRI.

Core ‘SOP 07: Data Flow, Monitoring, and Archiving’ was written under the assumption that a trial is sponsored by a pharmaceutical company that also takes the responsibility of monitoring according to Good Clinical Practice (GCP). The SOP 07a is a supplement to SOP 07 and describes the monitoring procedures in more detail. It is applicable if – The supplier of an investigational drug decides to...