In mammals, the primordial follicle pool, providing all oocytes available to a female throughout her reproductive life, is established perinatally. Dysregulation of primordial follicle assembly results in female reproductive diseases, such as premature ovarian insufficiency and infertility. Female mice lacking Dicer1 (Dicer), a gene required for biogenesis of microRNAs, show abnormal morphology...

background: investigation on the natural radionuclides 238u, 232th, 40k and natural fallout radionuclide 210po in the prominent plants species of western ghats tropical forest near kotagiri have been carried out as a part of baseline background radiation studies in the forest environment. materials and methods: the prominent plants species of the region evodia roxburghiana and eleaocarpus oblan...

This study compares the ultrastructure of murine embryonal carcinoma cells, the multipotential stem cells of teratocarcinomas, with the constituents of the primordial testicular tubules in which they arise. The primordial tubules were composed of Sertoli cells and primordial germinal cells ; the former were well differentiated with Golgi membranes and well developed cisternal endoplasmic reticu...

In mice, small oocytes (primordial oocytes) are enclosed within flattened granulosa cells to form primordial follicles around birth. A small number of primordial oocytes enter the growth phase, whereas others are quiescent. The mechanism regulating this selection of primordial oocytes is not well understood. The objective of the present study was to understand the role of p27(Kip1), which regul...

In theories with extra dimensions, the dependence of fundamental constants on the volume of the compact space allows one to use primordial nucleosynthesis to probe the structure of compact dimensions during the first few minutes after the big bang. Requiring the yield of primordial He to be within acceptable limits, we find that in ten-dimensional superstring models the size of the extra dimens...

This paper seeks to uncover dominant configurations of inter-organizational relationships across the USA and Japan in the automotive industry. We integrate relevant theoretical concepts from transaction cost economics, organization theory and political economy to develop a conceptual model of inter-organizational relationships based on the fit between information processing needs and informatio...

We present a novel synthesis algorithm for procedurally generating complex curves. Our approach takes a simple example input curve specified by a user and automatically generates complex curves that resemble the input. The algorithm preserves many of the input shape features such as tangent directions, curvature, branch nodes, and closed loops. The overall approach is simple and can be used to ...

*Correspondence: Antonio F. Miguel, Department of Physics, School of Sciences and Technology, University of Évora, Rua Romao Ramalho 59, 7000-671 Évora, Portugal e-mail: [email protected] The occurrence of configuration (design, shape, structure, rhythm) is a universal phenomenon that occurs in every flow system. Dendritic configuration (or tree-shaped configurations) is ubiquitous in nature and li...

Initiation of folliculogenesis through the induction of primordial follicle development in the ovary has an important role in determining the fertility and reproductive fitness of most mammalian species. The factors that control this critical process are largely unknown. The hypothesis tested in the current study was that kit-ligand/stem cell factor (KL) promotes the initiation and progression ...

The current study was designed to investigate the actions of Anti-Müllerian Hormone (AMH) on primordial follicle assembly. Ovarian primordial follicles develop from the breakdown of oocyte nests during fetal development for the human and immediately after birth in rodents. AMH was found to inhibit primordial follicle assembly and decrease the initial primordial follicle pool size in a rat ovari...