background and objective: the frequency and pattern of eye neoplasms differ in various geographic areas. our aim was to determine the distribution of patient age, gender, ocular tumor origin, location and histological type in our region. materials and methods: in this cross-sectional study, all of the 384 eye globe enucleation cases carried out during a 10-year period in farabi medical center i...

introduction: diagnosis, prediction and control of oral lesions is usually done classically based on clinical signs and histopathologic features. due to lack of timely diagnosis in all conventional methods or differential diagnosis, biopsy of patient is needed. therefore, the patient might be irritated. so, an intelligent method for quick and accurate diagnosis would be crucial. intelligent sys...

previous studies on etiology of squamous cell carcinoma (scc) of the tongue have reported results with respect to long term exposure to cigarette smoking and alcohol abuse. the aim of this study was to investigate risk factors for scc of the tongue in a set of patients with minimum exposure to cigarette smoking and alcohol. sixty four cases with diagnosis of oral tongue scc were reviewed in thi...

background: the aberrant expression of dickkopf-1 (dkk1), triose phosphate isomerase (tpi) and fatty acid binding-protein 5 (fabp5) in lung cancer tissues and their presence in secretome of lung cancer cell lines were reported. here, serum levels of these molecules in lung cancer patients were compared to those in a healthy control group. materials and methods: the patients’ group consisted of ...

abstract background: esophageal cancer is one of the major malignancies, with various epidemiological aspects in recent years in developing countries, including increased prevalence and variations of pathologic patterns. this may be due to increasing rates of barrett’s esophagus, gastroesophageal reflux, smoking and obesity. this study was performed from 1991 to 2005 in order to evaluate variou...

background and aim: squamous cell carcinoma is the eighth common cancer and forms 94% of oral malignancies. nowadays, many molecular and genetic changes have been known to affect tumoral behavior which might be good for drug production and gene therapy. it has been known that mutated p53, overexpression of p63 as an oncogene and hpv infection are correlated with clinicopathological behavior of ...

telomerase activation is one of the main pathways to immortalize cancer cells. in many kinds of cancer cells, this special reverse transcriptase stabilizes and elongates telomeres and prevents telomere erosion that naturally occurs in every cell division. esophageal cancer is the fifth most frequent cause of cancer death worldwide, and is highly associated with alcohol, smoking, cultural habits...

introduction: squamous cell carcinoma of the oral cavity is one of the most important and common types of head and neck malignancy, with an estimated rate of 4% among all human malignancies. the aim of this study was to determine the association between expression of matrix metalloproteinase 2 and 9 and the clinicopathological features of oral squamous cell carcinoma (oscc).   materials and met...

background cervical cancer is the leading cause of death from cancer in under-developed countries. human papilloma virus (hpv) 16 and 18 are the most prevalent types associated with carcinogenesis in the cervix. conventional polymerase chain reaction (pcr), type-specific and consensus primer-based pcr followed by sequencing, restriction fragment length polymorphism (rflp) or hybridization by sp...