PurposePrimary graft dysfunction (PGD) occurs in 1/3 of all lung transplants. It is defined by epithelial and innate immune cell infiltration. Natural killer (NK) cells are lymphocytes that activated NKG2D receptor binding specific stress molecules. We hypothesized NK mediate PGD recognizing molecules induced on causing injury via direct cytotoxicity.MethodsIn an established experimental model,...

Orthotopic liver transplantation (OLT) has become the effective treatment for end-stage liver diseases. Since the 1980s, the successful rate of liver transplantation has increased with the improvement of operative methods and the use of University of Wisconsin (UW) solution. Nevertheless, liver procurement and implantation are inevitably associated with allograft damage. Lack of donor liver hin...

myocardial dysfunction is a major complication in cardiac surgery that needs inotropic support. this study evaluates the effect of milrinone on patients with low ventricular ejection fraction undergoing off- pump coronary artery bypass graft (opcab). the present study is designed to evaluate the effect of milrinone on myocardial dysfunction. eighty patients with low ventricular ejection fractio...

Lung transplantation is a globally accepted treatment for some advanced lung diseases, giving the recipients longer survival and better quality of life. Since the first transplant successfully performed in 1983, more than 40 thousand transplants have been performed worldwide. Of these, about seven hundred were in Brazil. However, survival of the transplant is less than desired, with a high mort...

Lung transplantation is a well-accepted life-saving treatment for end-stage lung diseases. However, the short-term and long-term success of lung transplantation is hindered by multiple factors such as the shortage of organ donors, primary graft dysfunction, life-long immunosuppression and chronic graft dysfunction. Gene transfection presents a potential molecular therapeutic solution to these p...

Although graft survival following renal transplantation (RTx) has improved, outcomes following highrisk RTx are variable. Preexisting antibodies, including donor-specific antibodies (DSA), play an important role in graft dysfunction and survival. We have designed a study to investigate the safety and efficacy of anti-CD20 monoclonal antibodies (rituximab) in high-risk RTx recipients. Major elig...

BACKGROUND The once-daily (QD), prolonged-release formulation of tacrolimus has been shown to improve adherence versus twice-daily (BD) tacrolimus. Treatment nonadherence in transplant recipients has been associated with poor graft outcomes. METHODS This open-label, parallel-group study randomized adults with end-stage renal disease undergoing primary kidney transplantation or retransplantati...

INTRODUCTION Primary graft dysfunction is a major cause of mortality after heart transplantation. OBJECTIVE To evaluate correlations between donor-related clinical/biochemical markers and the occurrence of primary graft dysfunction/clinical outcomes of recipients within 30 days of transplant. METHODS The prospective study involved 43 donor/recipient pairs. Data collected from donors include...

PurposeThe increased use of donors after circulatory death (DCD) has expanded the breath organ donation across many heart transplant centers. However, there are concerns about stability and quality compared to traditional brain (DBD) organs. The objective our study is analyze differences between DCD DBD.MethodsSingle center, retrospective data from procured inception program at institution. We ...