Cutaneous lymphomas are classified according to their cellular origin into T-cell lymphoma and B-cell lymphoma. The annual incidence rate is 0.3 per 100,000 population. We report a case of a 56-year-old male patient who presented with a two-month history of nodules of varying sizes, some ulcerated, on the face, abdomen, and upper limbs. Histopathological examination and immunohistochemical stud...

We describe a patient with primary cutaneous small-tomedium--sized CD4+ T-cell lymphoma, according to the most recent World Health Organization (WHO) classification of cutaneous lymphomas. This lymphoma, previously known as primary cutaneous small-to-medium-sized pleomorphic CD4+ T-cell lymphoma, has a low incidence and good prognosis. The interest in the case presented in this report derives f...

Primary cutaneous lymphomas can be difficult to be distinguished from reactive mimics, even when integrating histologic, immunophenotypic, and clinical findings. Molecular studies, especially PCR-based antigen receptor gene rearrangement (ARGR) analysis, are frequently useful ancillary studies in the evaluation of cutaneous lymphoproliferations. The biologic basis of ARGR studies is discussed, ...

Discussion | In 1995, Benchikhi et al4 reported the first case of cutaneous B-cell lymphoma associated with follicular mucinosis in a patient with bone-marrow and peripheral blood infiltration.4We report the first caseof primary cutaneous follicle center lymphoma with follicular mucinosis. Cutaneous lymphomascanusuallybedistinguishedbyarchitectural features, where most atypical lichenoid infilt...

Cutaneous pseudolymphomas (CPLs) include a wide range of clinicopathological presentations sharing in common the presence of clinical and histopathological features mimicking those of primary cutaneous lymphomas. Although immunophenotypical studies and molecular analysis of clonality have been shown to be reliable tools, providing significant help in the differential diagnosis between primary c...

Primary cutaneous lymphomas are the second most common site of extranodal non-Hodgkin lymphoma. A specifically type named extranodal marginal zone B-cell lymphomas are indolent low-grade neoplasma.We report a case of a 42-year-old white man with multiple subcutaneous tumors located on the trunk and neck. The histopathological exam showed a non-epidermotropic, dense lymphocytic infiltrate. Histo...

CBCL: cutaneous B-cell lymphoma INTRODUCTION Cutaneous B-cell lymphomas (CBCL) are a heterogeneous group of lymphoproliferative diseases that can be classified in 2 broad categories: primary and secondary. The latter implies a systemic lymphoproliferative disease that causes visible cutaneous lesions. Numerous articles regarding the diagnosis and treatment of primary CBCL have been published. H...

Primary cutaneous lymphomas constitute a spectrum of diseases characterized by a clonal accumulation of lymphocytes in the skin. Cutaneous T-cell lymphomas of the cytotoxic phenotype, including CD8+ and CD56+ lymphomas, are rare entities that have only been recently recognized and characterized. These lymphomas often show an aggressive clinical course. We investigated the expression of human le...

Anaplastic large cell lymphomas are peripheral T-cell lymphomas that are characterized by a proliferation of large anaplastic blasts expressing CD30. In children, systemic anaplastic large cell lymphomas often present at advanced clinical stage and harbor translocations involving the anaplastic lymphoma kinase (ALK) gene leading to the expression of chimeric anaplastic lymphoma kinase (ALK)-fus...