نتایج جستجو برای: primary and metastatic melanoma

تعداد نتایج: 16947239  

Journal: :Hinyokika kiyo. Acta urologica Japonica 1987
Cumhur Selcuk Topal Gözde Kır Taner Daş Billur Sarbay Muzaffer İlkay Tosun

Metastatic bladder tumors constitute <5% of all bladder tumors and metastatic malignant melanoma of the urinary bladder is very rare. We present a case report of a metastatic malignant melanoma of the urinary bladder. A 70-year-old woman without any apparent significant clinical history was admitted to the Department of Urology for gross hematuria. Microscopic findings of the transurethral rese...

2016
M Mustafa Kılıçkaya Giray Aynali Ali Murat Ceyhan Metin Çiriş

Malignant melanoma of the parotid gland is often metastatic and mainly originates from malignant melanomas in the head and neck. Nevertheless, some malignant melanomas may metastasize and subsequently regress. Therefore, it may not be possible to observe a metastatic malignant melanoma and its primary melanoma simultaneously. The investigation of a patient's old photographs may help in the dete...

Journal: :Cell 2006
Minjung Kim Joseph D. Gans Cristina Nogueira Audrey Wang Ji-Hye Paik Bin Feng Cameron Brennan William C. Hahn Carlos Cordon-Cardo Stephan N. Wagner Thomas J. Flotte Lyn M. Duncan Scott R. Granter Lynda Chin

Genomes of human cancer cells are characterized by numerous chromosomal aberrations of uncertain pathogenetic significance. Here, in an inducible mouse model of melanoma, we characterized metastatic variants with an acquired focal chromosomal amplification that corresponds to a much larger amplification in human metastatic melanomas. Further analyses identified Nedd9, an adaptor protein related...

Journal: :Anticancer research 2014
Hans Michael Hau Hans-Michael Tautenhahn Markus Bo Schoenberg Georgi Atanasov Georg Wiltberger Mehmet Haluk Morgül Dirk Uhlmann Anna Theresa Seitz Jan C Simon Moritz Schmelzle Michael Bartels

BACKGROUND/AIM The aim of the present study was to define prognostic factors and to evaluate liver resection as an additive tool in metastatic melanoma. PATIENTS AND METHODS In a case-control study, 32 patients with hepatic melanoma metastasis were analyzed between 1998-2012. Sixteen patients who underwent liver resection (6 patients with multimodal therapy) were matched to 16 patients schedu...

2012
Rosaria Gangemi Valentina Mirisola Gaia Barisione Marina Fabbi Antonella Brizzolara Francesco Lanza Carlo Mosci Sandra Salvi Marina Gualco Mauro Truini Giovanna Angelini Simona Boccardo Michele Cilli Irma Airoldi Paola Queirolo Martine J. Jager Antonio Daga Ulrich Pfeffer Silvano Ferrini

Uveal melanoma is an aggressive cancer that metastasizes to the liver in about half of the patients, with a high lethality rate. Identification of patients at high risk of metastases may provide indication for a frequent follow-up for early detection of metastases and treatment. The analysis of the gene expression profiles of primary human uveal melanomas showed high expression of SDCBP gene (e...

Journal: :Anticancer research 2014
Tomas Olejar David Vetvicka Marie Zadinova Pavla Pouckova Jaromir Kukal Petr Jezek Radoslav Matej

AIM We investigated differences of metastatic spread of normal proteinase-activated receptor-2 (Par2+/+) melanoma B16 in Par2-/- (knock-out) animals compared to C57Bl6 mice. MATERIALS AND METHODS Nine knock-out mice B6.Cg-F2rl1tm1Mslb/J (Par2-/-) and nine C57Bl6/J controls were subcutaneously inoculated with B16 melanoma tissue cells. Twelve days after inoculation, all primary tumors were rem...

2013
Michael Z. Wang Jerry D. Brewer

No particular regimen is considered standard therapy for widespread metastatic melanoma, although surgery is the primary choice for regional nodal metastases. Systemic interleukin-2 (IL-2) is an effective immunotherapy for melanoma, but standard doses are associated with severe toxicity. We report a patient who was treated with intralesional low-dose IL-2 and V-beam pulsed dye laser for the tre...

2018
Nanumi Han Muhammad Baghdadi Kozo Ishikawa Hiraku Endo Takuto Kobayashi Haruka Wada Keisuke Imafuku Hiroo Hata Ken-ichiro Seino

Background Immunotherapies that target immune-checkpoint molecules such PD-1 have helped to achieve durable responses in melanoma treatment. However, 25% of melanoma patients who showed objective responses to PD-1 blockade develop resistance and suffer from disease progression and ultimately death, which necessitates the identification of related resistance mechanisms.IL-34 is a cytokine that c...

2015
Nour Kibbi Stephan Ariyan Frederick Slogoff Rossitza Lazova Jennifer Nam Choi

EMN: eruptive melanocytic nevi EMMM: epidermotropic metastatic malignant melanoma ITM: in-transit metastases INTRODUCTION Eruptive melanocytic nevi (EMN) are an unusual phenomenon characterized by the rapid appearance of multiple melanocytic nevi. Whether atypical or benign, EMN are associated with various medications and diseases but not previously with melanoma. EMN have been described in int...

2008
Viviana Vallacchi Maria Daniotti Francesca Ratti Delia Di Stasi Paola Deho Annamaria De Filippo Gabrina Tragni Andrea Balsari Antonino Carbone Licia Rivoltini Giorgio Parmiani Noureddine Lazar Bernard Perbal

CCN3/nephroblastoma overexpressed belongs to the CCN family of genes that encode secreted proteins associated with the extracellular matrix (ECM) and exert regulatory effects at the cellular level. Overexpression of CCN3 was shown in metastatic melanoma cells compared with cells of the primary tumor from the same patient. Analysis of short-term cultures from 50 primary and metastatic melanomas ...

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