In a prospective study we used phenobarbitone to treat 13 new patients with epilepsy (eight adults and five children). Full seizure control was achieved in 11 patients and poor compliance was documented in one of the remaining two patients (in both of whom seizures were reduced by over 50%). Doses sufficient to give mean steady state plasma levels of more than 43 mumol/l (10 microgram/ml) appea...

The European Diagnostic Working Group presented comprehensive diagnostic algorithms for cystic fibrosis (CF) and confirmed the fundamental role of the sweat test for the diagnosis of CF. However, several important differences between well-accepted guidelines for sweat testing 3 and the recommendations of the Working Group need to be discussed. An adequate sweat sampling volume depends on the sa...

The editors of IJE have commented on the surprising number of papers in their journal and other journals that fail to be cited even once. According to their most recent calculations, 17% of papers in IJE and 40% of those in Epidemiology achieve no recognition in the scientific literature. These numbers do not seem very plausible, so I decided to check. Using the most recent data available from ...

We study the problem of improving a machine learning model by identifying and using features that are not in the training set. This is applicable to machine learning systems deployed in an open environment. For example, a prediction model built on a set of sensors may be improved when it has access to new and relevant sensors at test time. To effectively use new features, we propose a novel app...