The immunogenicity results from 3 phase I trials of the Merck DNA human immunodeficiency virus (HIV) vaccine have previously been reported. Because preventive DNA vaccine strategies continue to be leveraged for diverse infections, the safety and tolerability results from these studies can inform the field moving forward, particularly regarding adverse reactions and adjuvants. No serious vaccine...

Background: Vaccination is one of the basic activities in preventive health care. Data related to vaccination in the elderly Turkish population is limited. The aim of the present study was to investigate the vaccination status and related factors among geriatric individuals. Methods: In this single center, cross sectional study self-reported status of vaccinations for influenza, pneumococcal, t...

In TB, prophylactic immunization plays a key preventive strategy. A live attenuated vaccine called bacille CalmetteGuérin (BCG) was developed way back in 1906 by Albert Calmette and Camille Guérin. The BCG vaccine was derived from an attenuated strain of Mycobacterium bovis and first used on humans in 1921 in France [2]. Currently the vaccine is given to neonates and children as a part of unive...

This commentary takes up Pearl's welcome challenge to clearly articulate the scientific value of principal stratification estimands that we and colleagues have investigated, in the area of randomized placebo-controlled preventive vaccine efficacy trials, especially trials of HIV vaccines. After briefly arguing that certain principal stratification estimands for studying vaccine effects on post-...

Tuberculosis is an important health problem in developing countries and the BCG vaccine plays an important part in preventing the disease. There are different reports about the preventive value of BCG. Some of them claim that it is satisfactory while others suggest that it provides little protection. There are also varying ideas about the optimum time to vaccinate babies, some studies suggestin...

Human enterovirus 71 (EV71) is a significant cause of morbidity and mortality from Hand, Foot and Mouth Disease (HFMD) and neurological complications, particularly in young children in the Asia-Pacific region. There are no vaccines or antiviral therapies currently available for prevention or treatment of HFMD caused by EV71. Therefore, the development of therapeutic and preventive strategies ag...

BACKGROUND In industrialized countries, assessment of the causal effect of physician supply on population health has yielded mixed results. Since the scope of child vaccination is an indicator of preventive health service utilization, this study investigates the correlation between vaccination coverage and pediatrician supply as a reflection of overall pediatric health during a time of increasi...