Lesions and temporary inactivation of the hippocampus (HPC) in rodents occasionally lead to discrepant amnesic effects. We directly compared and contrasted the retrograde amnesic effects that small HPC lesions (~50% damage), large HPC lesions (~80% damage), and combined dorsal and ventral HPC inactivation using the sodium channel blocker tetrodotoxin (TTX) had on contextual fear conditioning. C...

BACKGROUND The definition of hereditary prostate cancer (HPC) is based on family history and age at onset. Intuitively, HPC is a serious subtype of prostate cancer but there are only limited data on the clinical phenotype of HPC. Here, we aimed to compare the prognosis of HPC to the sporadic form of prostate cancer (SPC). METHODS HPC patients were identified through a national registry of HPC...

Cloud computing is emerging as an additional deployment option for some of the HPC applications. But still, it currently does not come without drawbacks for application performance. These performance issues take place due to resource contention, where one VM is able to impact the performance of another. This interference directly creates impact on performance and scalability of HPC application....

MapReduce (MR) has become a de facto standard for largescale data analysis. Moreover, it has also attracted the attention of the HPC community due to its simplicity, efficiency and highly scalable parallel model. However, MR implementations present some issues that may complicate its execution in existing HPC clusters, specially concerning the job submission. While on MR there are no strict par...

We investigated the effects of stem cell factor (SCF) on the migration of murine bone marrow hematopoietic progenitor cells (HPC) in vitro using a modification of the checkerboard assay. Chemotactic and chemokinetic activities of SCF on HPC were evaluated by the numbers of HPC migrated on positive and negative gradients of SCF, respectively. On both positive and negative gradients of SCF, HPC b...

This paper examines the issue of High-Performance Computing (HPC) platforms in undergraduate education and the Bootable Cluster CD (BCCD) to facilitate hands-on, classroom immersion in HPC topics. There is measurable benefits derived from teaching HPC topics through providing hands-on clustering experience to the students. Supporting an HPC environment for instruction, however, is accompanied b...

A biomimetic substrate for cell-culture is fabricated by plasma treatment of a prestressed thermoplastic shrink film to create tunable multiscaled alignment "wrinkles". Using this substrate, the functional alignment of human embryonic stem cell derived cardiomyocytes is demonstrated.

The 3-dimensional spatial organization of eukaryotic genomes is important for regulation of gene expression as well as DNA damage repair. It has been proposed that one basic biophysical property of all nuclei is that interphase chromatin must be kept in a condensed prestressed state in order to prevent entropic pressure of the DNA polymer from expanding and disrupting the nuclear envelope. Alth...

We investigated whether vascular endothelial growth factor (VEGF) production by human pulp cells (HPC) is regulated by lipopolysaccharide (LPS) in relation to the pathogenesis of pulpitis. Although HPC incubated with medium alone only marginally expressed VEGF mRNA and produced a low level of VEGF as detected by enzyme-linked immunosorbent assay, the VEGF mRNA expression and VEGF production wer...