A process for preparation of amides from unactivated esters and amines has been developed using a catalytic system comprised of group (IV) metal alkoxides in conjunction with additives including 1-hydroxy-7-azabenzotriazole (HOAt). In general, ester-amide exchange proceeds using a variety of structurally diverse esters and amines without azeotropic reflux to remove the alcohol byproduct. Initia...

Deaggregating the alkyl sodium NaCH2SiMe3 with polydentate nitrogen ligands enables preparation and characterisation of new, hydrocarbon soluble chelated alkylsodium reagents. Equipped significantly enhanced metalating power over their organolithium counterparts, these systems can promote controlled sodiation weakly acidic benzylic C−H bonds from a series toluene derivatives under mild stoichio...

A family of endogenous lipids, structurally analogous to the endogenous cannabinoid, N-arachidonoyl ethanolamine (Anandamide), and called N-acyl amides have emerged as a family of biologically active compounds at TRP receptors. N-acyl amides are constructed from an acyl group and an amine via an amide bond. This same structure can be modified by changing either the fatty acid or the amide to fo...

The development of new techniques for the preparation organic compounds is important, with catalytic processes being key to this innovation. copper-based metal-organic frameworks promote oxidative couplings has allowed synthesis amides in a very effective manner. This methodology been successfully applied unique bioactive compound N,N-diethyl-3-methylbenzamide, excellent performance (>99% co...

Pyrazine derivatives are important class of compounds with diverse biological and cytotoxic activities and clinical applications. In this study, B3 p 86 / 6 – 31 + + G * was used to compute and map the molecular surface electrostatic potentials of a group of substituted amides of pyrazine-2-carboxylic acids to identify common features related to their subsequent cytotoxicities. Several statisti...

Hydrosilylation of secondary and tertiary amides to amines is described using catalytic amounts of B(C6F5)3. The organic catalyst enables the reduction of amides with cost-efficient, non-toxic and air stable PMHS and TMDS hydrosilanes. The methodology was successfully extended to the more challenging reduction of primary amides.

A series of N-allenyl amides was prepared conveniently from N-propargyl amides in good to excellent yields via a modified procedure developed in this group. The palladium-catalyzed coupling-cyclization of these prepared N-allenyl amides in the presence of organic iodides has been developed affording the oxazoline derivatives efficiently.