Preterm delivery is the leading cause of neonatal mortality and contributes significantly to infant morbidity. Classical cyclooxygenase (COX) inhibitors, such as indomethacin, which inhibit both COX-1 and COX-2, are effective for delaying premature labor, but their use is limited by serious complications to the fetus and neonate, including adverse effects on the ductus arteriosus (DA). Using is...

  Preterm labor is one of the major causes of neonatal mortality and morbidity. Despite significant improvement in care for premature neonates, the most suitable and inexpensive treatment is prevention of preterm labor by inhibiting uterine contractions. The aim of this research is to obtain scientific evidence for the relaxant effect of ketotifen on the rat uterus and to provide the preclinica...

background: several studies have shown that administration of magnesium sulfate prolongs the bleeding time.   objective: to investigate such effects in pregnant women in shiraz, southern iran.   methods: this study was conducted on 30 pregnant women aged between 18 and 32 yrs, with a gestational age of 20 to 37 weeks, who presented to hafez and zeynabiyeh emergency units affiliated to shiraz un...

BACKGROUND Severe neonatal hyperbilirubinemia is associated with significant morbidity and mortality. This study was conducted to investigate the causes of severe hyperbilirubinemia leading to Exchange Transfusion (ET) from March 2009 to March 2011 in Bahrami children hospital, Tehran, Iran in order to establish guidelines to prevent profound jaundice & ET. METHODS 94 neonates underwent ET fo...

.........................................................................................................3 Dedication.......................................................................................................4 Acknowledgments.............................................................................................5 INTRODUCTION........................................................

Neonatal seizures continue to be a diagnostic and therapeutic challenge to the clinicians. Seizures can permanently disrupt neuronal development, induce synaptic reorganisation, reduce neurogenesis, alter plasticity and prime the brain to increased seizures later in life1. The prevalence of seizures is 2-3 /1000 live births in term and 10-15 /1000 in preterm deliveries2. Diagnostic and therapeu...

INTRODUCTION Universally mothers at 35 years or more have had higher maternal and perinatal risks. This study analyzed the trend of this group in maternal population and determined their risk of having premature children, during the demographic transition period in Chile. MATERIALS AND METHODS Epidemiological study conducted in the population of simple live births registered in the Chilean Na...

Fetal cholelithiasis is a rare finding during a third-trimester ultrasound with an average incidence rate of 0.07-1.15%. We report a case of fetal cholelithiasis in twins, observed in a patient with monochorionic diamniotic twin pregnancy hospitalized at our unit for signs of premature labor. We present the outcome of the 2 neonates with a clinical and sonographic follow-up. In addition, we off...

OBJECTIVE To compare the effectiveness and adverse effects of nifedipine versus indomethacin in the treatment of preterm labor. METHODS In a randomized clinical trial, 79 women with labor pain at 26-33 weeks of gestation were treated with either oral nifedipine (n=40) or rectal indomethacin (n=39). RESULTS Twenty-three (59%) women in the indomethacin group, and 10 (25%) in the nifedipine gr...

Objective Cervical length is often measured during the third trimester, especially in cases of threatened preterm labour. The gold standard is the transvaginal (TV) approach. A transabdominal approach is an alternative but it is often difficult to achieve a satisfactory image of the cervix in the third trimester. Transperineal (TP) ultrasound is considered less invasive and could offer a reliab...