In engineering design, an optimized solution often turns out to be suboptimal, when implementation errors are encountered. While the theory of robust convex optimization has taken significant strides over the past decade, all approaches fail if the underlying cost function is not explicitly given; it is even worse if the cost function is nonconvex. In this work, we present a robust optimization...

This study estimated time trade-off preference values associated with the four chronic myelogenous leukemia (CML) chronic phase-related health states (i.e. untreated, hematologic response, cytogenetic response and molecular response) among members of the general public in the UK (n = 241). All four health states were associated with decreases in preference values from full health. The molecular...

The preset response surface methodology (RSM) designs are commonly used in a wide range of process and design optimization applications. Although they offer ease of implementation and good performance, they are not sufficiently adaptive to reduce the required number of experiments and thus are not cost effective for applications with high cost of experimentation. We propose an efficient adaptiv...

The use of computer experiments and surrogate approximations (metamodels) introduces a source of uncertainty in simulation-based design that we term model interpolation uncertainty. Most existing approaches for treating interpolation uncertainty in computer experiments have been developed for deterministic optimization and are not applicable to design under uncertainty in which randomness is pr...

The electro discharge machining (EDM), one of the methods used in the machining industry and a non-traditional manufacturing method, the electro erosion process does not depend on the hardness of material and offers a way to process materials of very complex geometry with very fine and high precision by using cheap electrode materials, which make it a preferred method. In this study, effect of ...